In Situ Thermoreversible Gelling System of Riboflavin and Aminolevulinic Acid for Treatment of Keratoconus-affected Corneas of Mice

被引：0
作者：
Zhang, Li [1 ]
Zhang, Chunxia [2 ]
Dang, Hui [3 ]
机构：
[1] Jinan Second Peoples Hosp, Dept Pharm, 148 Jingyi Rd, Jinan 250001, Peoples R China
[2] Shandong First Med Univ, Jinan Maternal & Child Care Hosp, Dept Pharm, 2 Jianguo Xiaojing 3rd Rd, Jinan 250001, Peoples R China
[3] Jinan Second Peoples Hosp, Dept Ophthalmol, 148 Jingyi Rd, Jinan 250001, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2023年 / 42卷 / 05期
关键词：
aminolevulinic acid; cornea; in situ gel; keratoconus; riboflavin; OCULAR DELIVERY; GEL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study deals with the development of novel thermoreversible gel containing riboflavin and aminolevulinic acid for the treatment of keratoconus. The gel was prepared using Pluronic and sodium alginate. The formulated system was evaluated for various physico chemical parameters. The pH was found between 6.6 to 6.8 while gelation temperature was between 35 to 38 degrees C. All formulations were found isotonic and non-hemolytic in nature. The F5 formulation was found to be optimized considering all evaluation parameters. F5 formulation showed release of 98.21 and 99.2 % for riboflavin and aminolevulinic acid, respectively, within 8 h. The effect of formulation on keratoconus-affected mice showed that matrix can be produced after stimulation of human keratoconus cells (HKC) and the increased thickness can be the result of the increased number of cells. These results conclude the potential application of a thermoreversible gel containing riboflavin and aminolevulinic acid in keratoconus treatment.
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页码：1009 / 1015
页数：7
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