Ameliorative effects of zinc supplementation on cognitive function and hippocampal leptin signaling pathway in obese male and female rats

被引：10

作者：

Hafez, Lamia M. ^{[1
,2
]}

Aboudeya, Hebatallah Mohammed ^{[3
]}

Matar, Noura A. ^{[4
]}

El-Sebeay, Ashraf S. ^{[1
,2
]}

Nomair, Azhar Mohamed ^{[5
]}

El-hamshary, Shaymaa Ali ^{[6
]}

Nomeir, Hanan Mohamed ^{[7
]}

Ibrahim, Fawziya A. R. ^{[8
]}

机构：

[1] Reg Ctr Food, Human Nutr Dept, Alexandria, Egypt

[2] Feed Agr Res Ctr, Alexandria, Egypt

[3] Alexandria Univ, Med Res Inst, Human Physiol Dept, Alexandria, Egypt

[4] Alexandria Univ, Med Res Inst, Dept Histochem & Cell Biol, Alexandria, Egypt

[5] Alexandria Univ, Med Res Inst, Dept Chem Pathol, Alexandria, Egypt

[6] Alexandria Univ, Fac Sci, Biochem Dept, Alexandria, Egypt

[7] Alexandria Univ, Fac Med, Dept Med Biochem, Alexandria, Egypt

[8] Alexandria Univ, Med Res Inst, Appl Med Chem Dept, 165 Horreya Ave, Alexandria, Egypt

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

HOMEOSTASIS; DEFICIENCY;

D O I：

10.1038/s41598-023-31781-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity has been associated with cognitive impairments, increasing the probability of developing dementia. Recently, zinc (Zn) supplementation has attracted an increasing attention as a therapeutic agent for cognitive disorders. Here, we investigated the potential effects of low and high doses of Zn supplementation on cognitive biomarkers and leptin signaling pathway in the hippocampus of high fat diet (HFD)-fed rats. We also explored the impact of sex difference on the response to treatment. Our results revealed a significant increase in body weight, glucose, triglycerides (TG), total cholesterol (TC), total lipids and leptin levels in obese rats as compared to controls. HFD feeding also reduced brain-derived neurotrophic factor (BDNF) levels and increased acetylcholinesterase (AChE) activity in the hippocampus of both sexes. The low and high doses of Zn supplementation improved glucose, TG, leptin, BDNF levels and AChE activity in both male and female obese rats compared to untreated ones. Additionally, downregulated expression of leptin receptor (LepR) gene and increased levels of activated signal transducer and activator of transcription 3 (p-STAT3) that observed in hippocampal tissues of obese rats were successfully normalized by both doses of Zn. In this study, the male rats were more vulnerable to HFD-induced weight gain, most of the metabolic alterations and cognition deficits than females, whereas the female obese rats were more responsive to Zn treatment. In conclusion, we suggest that Zn treatment may be effective in ameliorating obesity-related metabolic dysfunction, central leptin resistance and cognitive deficits. In addition, our findings provide evidence that males and females might differ in their response to Zn treatment.

引用

页数：16