Ir-Catalyzed α-Alkylation of Methyl Ketones with Primary Carbohydrate Alcohols

被引：4

作者：

Tsuge, Kouki ^{[1
]}

Kubota, Shunnichi ^{[1
]}

Sakamoto, Kana ^{[1
]}

Kitayama, Kenji ^{[2
]}

Nishimura, Takahiro ^{[1
]}

机构：

[1] Osaka Metropolitan Univ, Grad Sch Sci, Dept Chem, Sumiyoshi, Osaka 5588585, Japan

[2] Daicel Corp, Grand Front Osaka Tower-B, 3-1,Ofuka Cho,Kita Ku, Osaka 5300011, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 07期

关键词：

Iridium; Sugars; Methyl Ketones; Alkylation; Hydrogen Transfer; BORROWING HYDROGEN; AMINES;

D O I：

10.1002/adsc.202300124

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Iridium-catalyzed alpha-alkylation of methyl ketones with primary carbohydrate alcohols proceeded via borrowing hydrogen strategy. Protected sugar derivatives having one free primary hydroxyl group reacted with methyl ketones to give the alpha-alkylation products or alkylated 4,5-unsaturated sugars along with the elimination of an alkoxy group.

引用

页码：971 / 975

页数：5

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