The provisional OMERACT ultrasonography score for giant cell arteritis

被引：51

作者：

Dejaco, Christian ^{[1
,2
]}

Ponte, Cristina ^{[3
,4
]}

Monti, Sara ^{[5
,6
]}

Rozza, Davide ^{[7
]}

Scire, Carlo Alberto ^{[8
]}

Terslev, Lene ^{[9
,10
]}

Bruyn, George A. W. ^{[11
]}

Boumans, Dennis ^{[12
]}

Hartung, Wolfgang ^{[13
]}

Hocevar, Alojzija ^{[14
,15
]}

Milchert, Marcin ^{[16
]}

Dohn, Uffe Moller ^{[17
]}

Mukhtyar, Chetan B. ^{[18
]}

Aschwanden, Markus ^{[19
]}

Bosch, Philipp ^{[1
]}

Camellino, Dario ^{[20
]}

Chrysidis, Stavros ^{[21
]}

Ciancio, Giovanni ^{[22
]}

D'Agostino, Maria Antonietta ^{[23
,24
]}

Daikeler, Thomas ^{[25
]}

Dasgupta, Bhaskar ^{[26
]}

De Miguel, Eugenio ^{[27
]}

Diamantopoulos, Andreas P. ^{[28
]}

Duftner, Christina ^{[29
]}

Agueda, Ana ^{[30
]}

Fredberg, Ulrich ^{[31
,32
]}

Hanova, Petra ^{[33
,34
]}

Hansen, Ib Tonder ^{[35
]}

Hauge, Ellen-Margrethe ^{[36
,37
]}

Iagnocco, Annamaria ^{[38
]}

Inanc, Nevsun ^{[39
]}

Juche, Aaron ^{[40
]}

Karalilova, Rositsa ^{[41
]}

Kawamoto, Toshio ^{[42
,43
]}

Keller, Kresten Krarup ^{[36
,37
]}

Keen, Helen Isobel ^{[44
]}

Kermani, Tanaz A. ^{[45
]}

Kohler, Minna J. ^{[46
]}

Koster, Matthew ^{[46
]}

Luqmani, Raashid Ahmed ^{[47
]}

Macchioni, Pierluigi ^{[48
]}

Mackie, Sarah Louise ^{[49
]}

Naredo, Esperanza ^{[50
,51
]}

Nielsen, Berit Dalsgaard ^{[36
,52
]}

Ogasawara, Michihiro ^{[43
]}

Pineda, Carlos ^{[53
]}

Schafer, Valentin Sebastian ^{[54
]}

Seitz, Luca ^{[55
]}

Tomelleri, Alessandro ^{[56
]}

Torralba, Karina D. ^{[57
]}

机构：

[1] Med Univ Graz, Dept Rheumatol, Graz, Steiermark, Austria

[2] Brunico Hosp, Dept Rheumatol, Trentino Alto Adige, Italy

[3] Ctr Hosp Univ Lisboa Norte, Ctr Acad Med Lisboa, Dept Rheumatol, Lisbon, Portugal

[4] Univ Lisbon, Ctr Acad Med Lisboa, Fac Med, Inst Med Mol,Rheumatol Res Unit, Lisbon, Portugal

[5] Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy

[6] Fdn IRCCS Policlin San Matteo, Div Rheumatol, Pavia, Italy

[7] Italian Soc Rheumatol, Milan, Italy

[8] Italian Soc Rheumatol SIR, Epidemiol Unit, Milan, Italy

[9] Rigshosp, Ctr Rheumatol & Spine Dis, Copenhagen, Denmark

[10] Univ Copenhagen, Clin Med, Copenhagen, Denmark

[11] Reumaklin Lelystad, Lelystad, Netherlands

[12] Hosp Grp Twente, Rheumatol & Clin Immunol, Almelo, Netherlands

[13] Asklepios Med Ctr, Rheumatol, Bad Abbach, Germany

[14] Univ Med Ctr Ljubljana, Dept Rheumatol, Ljubljana, Slovenia

[15] Univ Ljubljana, Med Fac, Ljubljana, Slovenia

[16] Pomeranian Med Univ, Dept Rheumatol Internal Med Geriatr & Clin Immuno, Szczecin, Poland

[17] Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis, Glostrup, Denmark

[18] Norfolk & Norwich Univ Hosp NHS Trust, Rheumatol Dept, Vasculitis Serv, Norwich, Norfolk, England

[19] Univ Hosp Basel, Angiol, Basel, Switzerland

[20] Azienda Sanitaria Locale 3 Genovese, Div Rheumatol, Dept Med Specialties, Genoa, Italy

[21] Sydvestjysk Sygehus Esbjerg, Rheumatol, Esbjerg, Denmark

[22] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[23] Fdn Policlin Univ A Gemelli, Rheumatol Dept, Rome, Italy

[24] INSERM, Paris, France

[25] Univ Hosp Basel, Clin Rheumatol, Basel, Switzerland

[26] Southend Univ Hosp, Mid & South Essex Univ Hosp NHS Fdn Trust, Westcliff On Sea, England

[27] Hosp Univ La Paz, Madrid, Spain

[28] Akershus Univ Hosp, Div Internal Med, Sect Rheumatol, Lorenskog, Norway

[29] Med Univ Innsbruck, Dept Internal Med, Clin Div Internal Med 2, Innsbruck, Austria

[30] Ctr Hosp Baixo Vouga EPE, Aveiro, Portugal

[31] Silkeborg Reg Hosp, Diagnost Ctr, Silkeborg, Denmark

[32] Odense Univ Hosp, Rheumatol, Odense, Denmark

[33] Inst Rheumatol, Rheumatol, Prague, Czech Republic

[34] Hana CB Spol Sro, Rheumatol, Ceske Budejovice, Czech Republic

[35] Aarhus Copenhagen Hosp, Dept Rheumatol, Aarhus, Denmark

[36] Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark

[37] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

[38] Univ Torino, Acad Rheumatol Ctr, Dipartimento Sci Clin & Biol, Turin, Italy

[39] Marmara Univ, Rheumatol, Sch Med, Istanbul, Turkey

[40] Immanuel Hosp, Dept Rheumatol, Berlin, Germany

[41] Med Univ Plovdiv, Clin Rheumatol, Plovdiv, Bulgaria

[42] Juntendo Univ, Immunol, Sch Med, Tokyo, Japan

[43] Juntendo Univ, Dept Internal Med & Rheumatol, Sch Med, Tokyo, Japan

[44] UWA, Med & Pharmacol, Perth, WA, Australia

[45] Univ Calif Los Angeles, David Geffen Sch Med, Rheumatol, Los Angeles, CA USA

[46] Harvard Med Sch, Div Rheumatol Allergy & Immunol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[47] Univ Oxford, Nuffield Dept Orthopaedicx Rheumatol & Musculoske, Oxford, England

[48] Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

[49] Univ Leeds, Leeds, W Yorkshire, England

[50] Hosp Univ Fdn Jimenez Diaz, Dept Rheumatol, IIS Fdn Jimenez Diaz, Madrid, Spain

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2023年 / 82卷 / 04期

关键词：

giant cell arteritis; ultrasonography; outcome assessment; health care; systemic vasculitis; ULTRASOUND; TOCILIZUMAB; SONOGRAPHY; TRIAL;

D O I：

10.1136/ard-2022-223367

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr(coeff) 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

引用

页码：556 / 564

页数：9

共 31 条

[1] Vessel wall plasticity in large vessel giant cell arteritis: an ultrasound follow-up study
Aschwanden, Markus
Schegk, Elke
Imfeld, Stephan
Staub, Daniel
Rottenburger, Christof
Berger, Christoph T.
Daikeler, Thomas
[J]. RHEUMATOLOGY, 2019, 58 (05) : 792 - 797
[2] Vascular involvement in patients with giant cell arteritis determined by duplex sonography of 2x11 arterial regions
Aschwanden, Markus
Kesten, Friederike
Stern, Martin
Thalhammer, Christoph
Walker, Ulrich A.
Tyndall, Alan
Jaeger, Kurt A.
Hess, Christoph
Daikeler, Thomas
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (07) : 1356 - 1359
[3] Ultrasound for diagnosis and follow-up of chronic axillary vasculitis in patients with long-standing giant cell arteritis
Bosch, Philipp
Dejaco, Christian
Schmidt, Wolfgang A.
Schlueter, Kenny D.
Pregartner, Gudrun
Schaefer, Valentin S.
[J]. THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2021, 13
[4] OMERACT Definitions for Ultrasonographic Pathologies and Elementary Lesions of Rheumatic Disorders 15 Years On
Bruyn, George A.
Iagnocco, Annamaria
Naredo, Esperanza
Balint, Peter V.
Gutierrez, Marwin
Hammer, Hilde B.
Collado, Paz
Filippou, Georgios
Schmidt, Wolfgang A.
Jousse-Joulin, Sandrine
Mandl, Peter
Conaghan, Philip G.
Wakefield, Richard J.
Keen, Helen I.
Terslev, Lene
D'Agostino, Maria Antonietta
Aydin, Sibel
Backhaus, Marina
Bachta, Artur
Chary-Valckenaere, Isabelle
Chrysidis, Stavros
Damjanov, Nemanja
Dasgupta, Bhaskar
Filippucci, Emilio
Gandjbachkh, Frederique
Filer, Andrew
Finzel, Stephanie
Hanova, Petra
Hocevar, Alojzija
Diaz, Cristina Hernandez
Ikeda, Kei
Inanc, Nevsun
Kaeley, Gurjit
Kortekaas, Marion
Lee, Gavin
Loeuille, Damien
Manzoni, Silvia Magni
Malattia, Clara
Micu, Mihaela
Moller, Ingrid
Pineda, Carlos
Ravagnani, Viviana
Richards, Bethan
Roth, Johannes
Schafer, Valentin
delle Sedie, Andrea
Skzudlarek, Marcin
Tzaribachev, Nicolas
Sahbudin, Ilfita
Stoenoiu, Maria
[J]. JOURNAL OF RHEUMATOLOGY, 2019, 46 (10) : 1388 - 1393
[5] Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: a study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group
Chrysidis, Stavros
Duftner, Christina
Dejaco, Christian
Schaefer, Valentin S.
Ramiro, Sofia
Carrara, Greta
Scire, Carlo Alberto
Hocevar, Alojzija
Diamantopoulos, Andreas P.
Iagnocco, Annamaria
Mukhtyar, Chetan
Ponte, Cristina
Naredo, Esperanza
De Miguel, Eugenio
Bruyn, George A.
Warrington, Kenneth J.
Terslev, Lene
Milchert, Marcin
D'Agostino, Maria Antonietta
Koster, Mattew J.
Rastalsky, Naina
Hanova, Petra
Macchioni, Pierluigi
Kermani, Tanaz A.
Lorenzen, Tove
Dohn, Uffe Moller
Fredberg, Ulrich
Hartung, Wolfgang
Dasgupta, Bhaskar
Schmidt, Wolfgang A.
[J]. RMD OPEN, 2018, 4 (01):
[6] Efficacy and safety of mavrilimumab in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial
Cid, Maria C.
Unizony, Sebastian H.
Blockmans, Daniel
Brouwer, Elisabeth
Dagna, Lorenzo
Dasgupta, Bhaskar
Hellmich, Bernhard
Molloy, Eamonn
Salvarani, Carlo
Trapnell, Bruce C.
Warrington, Kenneth J.
Wicks, Ian
Samant, Manoj
Zhou, Teresa
Pupim, Lara
Paolini, John F.
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (05) : 653 - 661
[7] De Miguel E, 2012, CLIN EXP RHEUMATOL, V30, pS34
[8] EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice
Dejaco, Christian
Ramiro, Sofia
Duftner, Christina
Besson, Florent L.
Bley, Thorsten A.
Blockmans, Daniel
Brouwer, Elisabeth
Cimmino, Marco A.
Clark, Eric
Dasgupta, Bhaskar
Diamantopoulos, Andreas P.
Direskeneli, Haner
Iagnocco, Annamaria
Klink, Thorsten
Neill, Lorna
Ponte, Cristina
Salvarani, Carlo
Slart, Riemer H. J. A.
Whitlock, Madeline
Schmidt, Wolfgang A.
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (05) : 636 - 643
[9] Giant cell arteritis and polymyalgia rheumatica: current challenges and opportunities
Dejaco, Christian
Brouwer, Elisabeth
Mason, Justin C.
Buttgereit, Frank
Matteson, Eric L.
Dasgupta, Bhaskar
[J]. NATURE REVIEWS RHEUMATOLOGY, 2017, 13 (10) : 578 - 592
[10] The spectrum of giant cell arteritis and polymyalgia rheumatica: revisiting the concept of the disease
Dejaco, Christian
Duftner, Christina
Buttgereit, Frank
Matteson, Eric L.
Dasgupta, Bhaskar
[J]. RHEUMATOLOGY, 2017, 56 (04) : 506 - 515

← 1 2 3 4 →