Photo-Activated Ratiometric Fluorescent Indicator for Real-Time and Visual Detection of Plasma Membrane Homeostasis

被引：7

作者：

Bu, Yingcui ^{[1
]}

Wang, Haoran ^{[2
]}

Deng, Yu ^{[1
]}

Zhong, Feng ^{[1
]}

Yu, Zhi-peng ^{[1
]}

Zhu, Xiaojiao ^{[1
]}

Zhou, Hongping ^{[1
]}

机构：

[1] Anhui Univ, Key Lab Struct & Funct Regulat Hybrid Mat, Key Lab Funct Inorgan Mat Chem, Inst Phys Sci & Informat Technol,Anhui Province Ke, Hefei 230601, Peoples R China

[2] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2023年 / 95卷 / 03期

基金：

中国国家自然科学基金;

关键词：

AGGREGATION-INDUCED EMISSION; PHOTODYNAMIC THERAPY; CANCER-CELLS; VISCOSITY; PROBE; PHOTOSENSITIZER; RESISTANCE; AUTOPHAGY;

D O I：

10.1021/acs.analchem.2c02793

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Development of an activated ratiometric indicator that is specific to plasma membrane (PM) viscosity exhibits great application prospects in disease diagnosis and treatment but remains a great challenge. Herein, a photo-activated fluorescent probe (CQ-IC) was designed and prepared tactfully, which could analyze and real-time monitor the microenvironmental homeostasis of the PM based on a two-channel ratiometric imaging model. Interestingly, upon light irradiation, CQ-IC generates reactive oxygen species and thus increases the cellular viscosity, which increases two emission peaks at 480 and 610 nm. This work would propose a new strategy to sensor PM homeostasis and effectively guide the treatment of viscosity-related diseases among various physiological and patho-logical processes.

引用

页码：1838 / 1846

页数：9

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