Liver-Related Mortality in Hepatitis B Virus Core Antibody plus /Hepatitis B Virus Surface Antigen - Patients: Occult Hepatitis B Virus, Hepatitis B Virus Reactivation, and Hepatocellular Carcinoma Development

被引:4
作者
Jung, Janghan [1 ,2 ]
Nguyen, Mindie H. [1 ,3 ]
机构
[1] Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94305 USA
[2] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Hwaseong, Gyeonggi, South Korea
[3] Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Palo Alto, CA 94305 USA
关键词
D O I
10.14309/ajg.0000000000002030
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Although hepatitis B virus surface antigen (HBsAg) serum clearance is an important milestone in the natural history of chronic hepatitis B virus (HBV) infection, HBsAg-negative patients are at risk of liver cancer and liver-related death, especially when progressive fibrosis is present. HBsAg-negative/anti-HBV core antibody-positive patients should be carefully evaluated and managed accordingly for the presence of significant liver fibrosis, other viral coinfections, occult HBV infection, risk of HBV reactivation, and hepatocellular carcinoma. Antiviral prophylaxis should be initiated in isolated anti-HBV core antibody patients receiving high-risk chemotherapy or biologics. Hepatocellular carcinoma surveillance with liver ultrasound and serum alpha-fetoprotein should be considered for patients with risk factors.
引用
收藏
页码:24 / 25
页数:2
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