Unveiling the Potential of Therapeutic Mesenchymal Stem Cells in Cancer Treatment

被引：0
|
作者：
Mallu, Maheswara Reddy [1 ]
Amarthaluri, Santhi Priya [2 ]
Biwas, Kamalika [1 ]
Arsavalli, Anusha [1 ]
Durbhakula, Namrata [1 ]
Bandaru, Sai Kerthana [1 ]
Kodavaty, Jagadeeshwar [3 ]
Erva, Rajeswara Reddy [4 ]
机构：
[1] Koneru Lakshmaiah Educ Fdn, Dept Biotechnol, Guntur, Andhra Pradesh, India
[2] Sri Venkateshwara Coll Pharm, Dept Biotechnol, Hyderabad, Telangana, India
[3] Univ Petr & Energy Studies UPES, Dept Chem Engn, Dehra Dun 248007, Uttaranchal, India
[4] NIT Andhra Pradesh, Dept Biotechnol, Tadepalligudem, Andhra Pradesh, India
来源：
ASIAN JOURNAL OF PHARMACEUTICS | 2023年 / 17卷 / 04期
关键词：
Anti-proliferative agents; mesenchymal stem cells; pro-apoptotic factors; targetted therapy; tumor micro environment; UMBILICAL-CORD BLOOD; BONE-MARROW; TARGETED-DELIVERY; METASTASES; MIGRATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Recent studies have suggested that mesenchymal stem cells (MSC) can migrate to tumor-specific regions and stem cell-based therapies have potential in treating several cancers. Such cells are genetically modified to express certain pro-apoptotic factors, pro-drugs, anti-proliferative agents, therapeutic proteins, and anti-angiogenic agents at the tumor sites. It is also evident that new modalities of cancer therapies are needed immediately which would push this research to the clinic and render MSCs as potential vectors for targeted therapy. The current review focuses on different sources of MSC used against tumors, the interactions and behavior of MSCs in the tumor microenvironment, and the usage of MSC as delivery vectors.
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收藏
页码：670 / 673
页数：4
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