Presynaptic Protein Synthesis in Brain Function and Disease

被引：6
作者：
Castillo, Pablo E. [1 ,2 ]
Jung, Hosung [3 ]
Klann, Eric [4 ,5 ]
Riccio, Antonella [6 ]
机构：
[1] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10461 USA
[3] Yonsei Univ, Grad Sch Med Sci, Dept Anat, Brain Korea 21 Project,Coll Med, Seoul 03722, South Korea
[4] New York Univ, Ctr Neural Sci, New York, NY 10003 USA
[5] New York Univ, Grossman Sch Med, Neurosci Inst, New York, NY 10016 USA
[6] UCL, UCL Lab Mol Cell Biol, London WC1E 6BT, England
来源：
JOURNAL OF NEUROSCIENCE | 2023年 / 43卷 / 45期
基金：
英国医学研究理事会; 新加坡国家研究基金会; 英国惠康基金; 美国国家卫生研究院;
关键词：
FRAGILE-X-SYNDROME; LONG-TERM PLASTICITY; MESSENGER-RNA; LOCAL TRANSLATION; SYNAPTIC PLASTICITY; MEMORY CONSOLIDATION; INITIATION-FACTORS; MAINTENANCE; TRANSCRIPTOME; LOCALIZATION;
D O I：
10.1523/JNEUROSCI.1454-23.2023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Local protein synthesis in mature brain axons regulates the structure and function of presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial mechanism underlies experience-dependent modifications of brain circuits, and its dysregulation may contribute to brain disorders, such as autism and intellectual disability. Here, we discuss recent advancements in the axonal transcriptome, axonal RNA localization and translation, and the role of presynaptic local translation in synaptic plasticity and memory.
引用
收藏
页码：7483 / 7488
页数：6
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