Arterial Stiffness in Patients with Bipolar Disorder

被引:2
作者
Kilicaslan, Asli Kazgan [1 ]
Emir, Burcu Sirlier [2 ]
Yildiz, Sevler [3 ]
Kilicaslan, Gulhan [4 ]
Kurt, Osman [5 ]
机构
[1] Univ Bozok, Dept Psychiat, Ataturk Rd 7, TR-66100 Yozgat, Turkiye
[2] Elazig Fethi Sekin City Hosp, Dept Psychiat, Elazig, Turkiye
[3] Univ Binali Yildirim, Dept Psychiat, Erzincan, Turkiye
[4] Elazig Fethi Sekin City Hosp, Dept Radiol, Elazig, Turkiye
[5] Adiyaman Prov Hlth Directorate, Adiyaman, Turkiye
关键词
Arterial stiffness; Bipolar disorder; Cardiovascular risks; Elastic modulus; Carotid intima-media thickness; Femoral artery; PULSE-WAVE VELOCITY; ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR RISK; SCHIZOPHRENIA; DYSFUNCTION; CYTOKINES; NETWORK; PROTEIN; LITHIUM;
D O I
10.9758/cpn.22.1009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: Bipolar disorder (BD) is an inflammatory and metabolic disease. The disease and the drugs used to treat it may affect cardiovascular disease (CVD) risk. The aim of this study is to investigate arterial stiffness in patients with BD and compare them with healthy controls. Methods: Thirty-nine patients with BD type I in remission and 39 healthy control subjects were included in the study. Carotid and femoral artery intima-media thickness (IMT) and arterial thickness parameters were measured by Doppler ultrasonography. Results: The elastic modulus value of the carotid artery was significantly higher in the patients than in the control group (p = 0.015). Although the IMT of both carotid and femoral artery was thicker in patients than in healthy control subjects, this difference was not statistically significant (p = 0.105; p = 0.391). There was a significant positive correlation between chlorpromazine equivalent dose and femoral elastic modulus value (p = 0.021, r = 0.539). There was a positive correla-tion between lithium equivalent dose and carotid compliance; a significant negative correlation between lithium equiv-alent dose and carotid elastic modulus was also determined (both p = 0.007, r = 0.466; p = 0.027, r = -0.391, respect-ively). No predictor was observed between drug dose and arterial stiffness parameters. Conclusion: Arterial stiffness might be investigated for its potential to reduce CVD risk in patients with BD. Given the established CVD complications in this patient population, further studies are needed to determine whether the results are specific to antipsychotic treatment or BD and to clarify the potential arterial protective effects of mood stabilizers.
引用
收藏
页码:516 / 525
页数:10
相关论文
共 43 条
[1]   Evaluation of arterial stiffness in patients with schizophrenia [J].
Baykara, Sema ;
Bozdag, Pinar Gundogan ;
Baykara, Murat ;
Namli, Mustafa Nuray .
JOURNAL OF CLINICAL NEUROSCIENCE, 2020, 79 :149-153
[2]   A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation [J].
Bosche, Bert ;
Molcanyi, Marek ;
Noll, Thomas ;
Rej, Soham ;
Zatschler, Birgit ;
Doeppner, Thorsten R. ;
Hescheler, Juergen ;
Mueller, Daniel J. ;
Macdonald, R. Loch ;
Haertel, Frauke V. .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2016, 67 :98-106
[3]   Arterial Stiffness and Cardiovascular Risk in Hypertension [J].
Boutouyrie, Pierre ;
Chowienczyk, Phil ;
Humphrey, Jay D. ;
Mitchell, Gary F. .
CIRCULATION RESEARCH, 2021, 128 (07) :864-886
[4]  
Centorrino F, 2006, CLIN NEUROPSYCHIATR, V3, P322
[5]   Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser116 signaling cascade in endothelial cells and mice [J].
Cho, Du-Hyong ;
Park, Jung-Hyun ;
Lee, Eun Joo ;
Won, Kyung Jong ;
Lee, Sang-Hee ;
Kim, Yang-Hoon ;
Hwang, Soojin ;
Kwon, Kyoung Ja ;
Shin, Chan Young ;
Song, Kee-Ho ;
Jo, Inho ;
Han, Seol-Heui .
FREE RADICAL BIOLOGY AND MEDICINE, 2014, 76 :96-106
[6]   Vasculopathy Related to Manic/Hypomanic Symptom Burden and First-Generation Antipsychotics in a Sub-Sample from the Collaborative Depression Study [J].
Fiedorowicz, Jess G. ;
Coryell, William H. ;
Rice, John P. ;
Warren, Lois L. ;
Haynes, William G. .
PSYCHOTHERAPY AND PSYCHOSOMATICS, 2012, 81 (04) :235-243
[7]   Arterial Stiffness in Patients Taking Second-generation Antipsychotics [J].
Findikli, Ebru ;
Gokce, Mustafa ;
Nacitarhan, Vedat ;
Camkurt, Mehmet Akif ;
Findikli, Huseyin Avni ;
Kardas, Selcuk ;
Sahin, Merve Cosgun ;
Karaaslan, Mehmet Fatih .
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 2016, 14 (04) :365-370
[8]   Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice [J].
Francois, Arnaud ;
Terro, Faraj ;
Quellard, Nathalie ;
Fernandez, Beatrice ;
Chassaing, Damien ;
Janet, Thierry ;
Bilan, Agnes Rioux ;
Paccalin, Marc ;
Page, Guylene .
MOLECULAR BRAIN, 2014, 7
[9]   Postmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review [J].
Giridharan, Vijayasree V. ;
Sayana, Pavani ;
Pinjari, Omar F. ;
Ahmad, Naveed ;
da Rosa, Maria Ines ;
Quevedo, Joao ;
Barichello, Tatiana .
MOLECULAR PSYCHIATRY, 2020, 25 (01) :94-113
[10]   Excessive and Premature New-Onset Cardiovascular Disease Among Adults With Bipolar Disorder in the US NESARC Cohort [J].
Goldstein, Benjamin I. ;
Schaffer, Ayal ;
Wang, Shuai ;
Blanco, Carlos .
JOURNAL OF CLINICAL PSYCHIATRY, 2015, 76 (02) :163-169