Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

被引:4
作者
Aldayyeni, Hussein [1 ]
Hjazi, Ahmed [2 ]
Shahab, Sana [3 ]
Gupta, Jitendra [4 ]
Alsaab, Hashem O. [5 ]
Motea, Yaseen Hasan [6 ]
Alazbjee, Adeeb Abdulally Abdulhussien [7 ]
Romero-Parra, Rosario Mireya [8 ]
Obaid, Rasha Fadhel [9 ]
Hussien, Beneen M. [10 ]
Hosseini-Fard, Seyed Reza [11 ]
机构
[1] Nottingham Univ Hosp, NHS Trust, Nottingham, England
[2] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al-Kharj 11942, Saudi Arabia
[3] Princess Nourah Bint Abdulrahman Univ, Coll Business Adm, Dept Business Adm, POB 84428, Riyadh 11671, Saudi Arabia
[4] GLA Univ, Inst Pharmaceut Res, Mathura 281406, Uttar Pradesh, India
[5] Taif Univ, Dept Pharmaceut & Pharmaceut Technol, Taif 21944, Saudi Arabia
[6] Al Bayan Univ, Coll Dent, Baghdad, Iraq
[7] Al Ayen Univ, Coll Med, Nasiriyah, Iraq
[8] Univ Continental, Lima, Peru
[9] Al Mustaqbal Univ Coll, Dept Biomed Engn, Babylon, Iraq
[10] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq
[11] Univ Tehran Med Sci, Fac Med, Dept Biochem, Tehran, Iran
关键词
Cancer; LINC00857; LncRNA; Oncogene; NONCODING RNA LINC00857; OVARIAN-CANCER; CELL-PROLIFERATION; APOPTOSIS; PROGRESSION; RESISTANCE; DIAGNOSIS; OSTEOSARCOMA; EXPRESSION; PREVENTION;
D O I
10.1007/s13577-023-00936-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial-mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications.
引用
收藏
页码:1656 / 1671
页数:16
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