Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke

被引：4
作者：
Namestnikova, D. D. [1 ,2 ]
Gubskiy, I. L. [1 ,2 ]
Cherkashova, E. A. [1 ,2 ]
Sukhinich, K. K. [3 ]
Melnikov, P. A. [4 ]
Gabashvili, A. N. [5 ]
Kurilo, V. V. [2 ]
Chekhonin, V. P. [2 ,4 ]
Gubsky, L. V. [1 ,2 ]
Yarygin, K. N. [3 ,6 ]
机构：
[1] Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
[2] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia
[3] VN Orekhovich Res Inst Biomed Chem, Moscow, Russia
[4] Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia
[5] Natl Res Technol Univ MISiS, Moscow, Russia
[6] Russian Med Acad Continuous Profess Educ, Minist Hlth Russian Federat, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期
关键词：
cell therapy; mesenchymal stem cells; ischemic stroke; middle cerebral artery occlusion model; intracerebral administration; CEREBRAL-ARTERY OCCLUSION; BONE-MARROW; STROMAL CELLS; METAANALYSIS; DIFFERENTIATION; NEUROGENESIS; RECOVERY; DELIVERY;
D O I：
10.1007/s10517-023-05822-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
引用
收藏
页码：116 / 125
页数：10
相关论文
共 55 条
  • [1] Neurogenesis in adult subventricular zone
    Alvarez-Buylla, A
    García-Verdugo, JM
    [J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (03) : 629 - 634
  • [2] Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats
    Bao, Xinjie
    Wei, Junji
    Feng, Ming
    Lu, Shan
    Li, Guilin
    Dou, Wanchen
    Ma, Wenbin
    Ma, Sihai
    An, Yihua
    Qin, Chuan
    Zhao, Robert Chunhua
    Wang, Renzhi
    [J]. BRAIN RESEARCH, 2011, 1367 : 103 - 113
  • [3] The dark side of the force - constraints and complications of cell therapies for stroke
    Boltze, Johannes
    Arnold, Antje
    Walczak, Piotr
    Jolkkonen, Jukka
    Cui, Lili
    Wagner, Daniel-Christoph
    [J]. FRONTIERS IN NEUROLOGY, 2015, 6
  • [4] Concise Review: Stem Cell Therapy for Stroke Patients: Are We There Yet?
    Borlongan, Cesario, V
    [J]. STEM CELLS TRANSLATIONAL MEDICINE, 2019, 8 (09) : 983 - 988
  • [5] Mesenchymal Stromal Cells in Ischemic Brain Injury
    Brooks, Beverly
    Ebedes, Dominique
    Usmani, Ahsan
    Vega Gonzales-Portillo, Joaquin
    Gonzales-Portillo, Daniel
    Borlongan, Cesario, V
    [J]. CELLS, 2022, 11 (06)
  • [6] Standardization of Biochemical Profile of Mesenchymal Cell Materials by Probing the Level of Dehydrogenase Activity
    Burunova, V. V.
    Gisina, A. M.
    Kholodenko, I. V.
    Lupatov, A. Yu.
    Shragina, O. A.
    Yarygin, K. N.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 149 (04) : 497 - 501
  • [7] Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia
    Cherkashova, E. A.
    Namestnikova, D. D.
    Gubskiy, I. L.
    Revkova, V. A.
    Sukhinich, K. K.
    Mel'nikov, P. A.
    Chekhonin, V. P.
    Gubsky, L. V.
    Yarygin, K. N.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 173 (04) : 514 - 518
  • [8] Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain
    Darsalia, Vladimer
    Allison, Susan J.
    Cusulin, Carlo
    Monni, Emanuela
    Kuzdas, Daniela
    Kallur, Therese
    Lindvall, Olle
    Kokaia, Zaal
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (01) : 235 - 242
  • [9] Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect
    Fischer, Uwe M.
    Harting, Matthew T.
    Jimenez, Fernando
    Monzon-Posadas, Werner O.
    Xue, Hasen
    Savitz, Sean I.
    Laine, Glen A.
    Cox, Charles S., Jr.
    [J]. STEM CELLS AND DEVELOPMENT, 2009, 18 (05) : 683 - 691
  • [10] The dynamic in vivo distribution of bone marrow-derived mesenchymal stent cells after infusion
    Gao, JZ
    Dennis, JE
    Muzic, RF
    Lundberg, M
    Caplan, AI
    [J]. CELLS TISSUES ORGANS, 2001, 169 (01) : 12 - 20
123456