Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke

被引：5
作者：
Namestnikova, D. D. [1 ,2 ]
Gubskiy, I. L. [1 ,2 ]
Cherkashova, E. A. [1 ,2 ]
Sukhinich, K. K. [3 ]
Melnikov, P. A. [4 ]
Gabashvili, A. N. [5 ]
Kurilo, V. V. [2 ]
Chekhonin, V. P. [2 ,4 ]
Gubsky, L. V. [1 ,2 ]
Yarygin, K. N. [3 ,6 ]
机构：
[1] Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
[2] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia
[3] VN Orekhovich Res Inst Biomed Chem, Moscow, Russia
[4] Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia
[5] Natl Res Technol Univ MISiS, Moscow, Russia
[6] Russian Med Acad Continuous Profess Educ, Minist Hlth Russian Federat, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期
关键词：
cell therapy; mesenchymal stem cells; ischemic stroke; middle cerebral artery occlusion model; intracerebral administration; CEREBRAL-ARTERY OCCLUSION; BONE-MARROW; STROMAL CELLS; METAANALYSIS; DIFFERENTIATION; NEUROGENESIS; RECOVERY; DELIVERY;
D O I：
10.1007/s10517-023-05822-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
引用
收藏
页码：116 / 125
页数：10
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