Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis

被引：7

作者：

Hosseini, Sareh ^{[1
]}

Soltani-Zangbar, Mohammad Sadegh ^{[2
,3
]}

Zamani, Majid ^{[4
]}

Yaghoubi, Yoda ^{[3
]}

Ghiasi, Reza Rikhtegar ^{[5
]}

Motavalli, Roza ^{[3
]}

Ghassabi, Ali ^{[3
]}

Iranzad, Rahim ^{[3
]}

Mehdizadeh, Amir ^{[6
]}

Shakouri, Seyed Kazem ^{[1
]}

Pishgahi, Alireza ^{[1
]}

Yousefi, Mehdi ^{[3
,5
,7
]}

机构：

[1] Tabriz Univ Med Sci, Phys Med & Rehabil Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[3] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[4] Gonabad Univ Med Sci, Fac Allied Med, Infect Dis Res Ctr, Dept Med Lab Sci, Gonabad, Iran

[5] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran

[6] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Tabriz, Iran

[7] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Immunol, Tabriz, Iran

来源：

GROWTH FACTORS | 2023年 / 41卷 / 03期

关键词：

Knee osteoarthritis; platelet-rich plasma; platelet lysate; KOA therapy; INTRAARTICULAR INJECTIONS; ARTICULAR-CARTILAGE; HYALURONIC-ACID; SYNOVIAL-FLUID; DOUBLE-BLIND; INFLAMMATION; EXOSOMES; EFFICACY; OUTCOMES; STRESS;

D O I：

10.1080/08977194.2023.2227273

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured by ELISA. All patients showed significant improvements in pain and function following treatment of KOA with PL and PRP compared to baseline. Moreover, PL's concentration of growth factors was significantly higher than PRP. A significant increase was also observed in all of the aforementioned mediators in both PRP and PL products compared to control. These results can introduce PL as a promising and alternative option for KOA therapy in the future.

引用

页码：165 / 177

页数：13

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