Regulation of immune function in healthy adults: one-stop guide on the role of dietary fatty acids, gut microbiota-derived short chain fatty acids, and select micronutrients in combination with physical activity

被引:11
作者
Patel, Dhruvesh [1 ]
Evanchuk, Jenna [1 ]
Wang, Ren [1 ]
Dunbar, Carolyn L. [1 ]
Munhoz, Jaqueline [1 ]
Field, Catherine J. [1 ]
机构
[1] Univ Alberta, Dept Agr Food & Nutr Sci AFNS, Edmonton, AB, Canada
关键词
nutrition; immunity; infection; inflammation; selenium; zinc; vitamin D; physical activity; MUFA; PUFA; ALPHA-LINOLENIC ACID; VIRGIN OLIVE OIL; INFLAMMATORY MARKERS; VITAMIN-D; PUFA SUPPLEMENTATION; ENDOTHELIAL FUNCTION; CYTOKINE PRODUCTION; OXIDATIVE STRESS; VEGETABLE-OILS; FISH-OIL;
D O I
10.1139/apnm-2022-0456
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The immune system requires an adequate supply of nutrients, although current dietary recommendations may not account for optimal immune function in healthy adults. Nutrient inadequacies due to the growing influence of the western diet pose a risk for immune dysfunction. This review aims to determine the beneficial effects of supplementing dietary fats, nutrients that modulate gut microbiota, and specific micronutrients on systemic immune functions (concentrations of plasma cytokines, antibodies, and acute phase proteins) during health and acute inflammatory conditions, including COVID-19. We discussed micronutrients (selenium, zinc, and vitamin D) with compelling evidence supporting immunomodulatory properties. Additionally, the synergistic effects of physical activity and dietary interventions on systemic immune markers are explored. Briefly, evidence suggests that dietary consumption of monounsaturated (oleic and palmitoleic acids) and omega-3 polyunsaturated fatty acids (eicosapentaenoic and docosahexaenoic acids) promotes anti-inflammatory properties. Food sources (fiber, prebiotics, probiotics, omega-3) and patterns (Mediterranean diet) increase the production of short-chain fatty acids, beneficially altering gut microbiota composition, which subsequently enhances the immunomodulatory properties of circulating immune cells. A positive synergistic role of nutrient supplementation (omega-3 and fiber) and physical activity on circulating C-reactive protein and interleukin-6 levels has been observed. Lastly, omega-3 supplementation during COVID-19 infection may reduce circulating C-reactive protein and pro-inflammatory cytokines and improves pain and fatigue symptoms. This review highlights recent findings that support the beneficial role of specific nutrients in promoting systemic immune function in healthy adults. However, to establish specific dietary recommendations to support optimal immune function, more research is required. Key takeaway: Increasing dietary fats (fish and olive oils) and specific micronutrients may positively impact systemic immune function in healthy adults. Evidence suggests that these nutrients promote immunomodulatory properties useful in resolving acute infection.
引用
收藏
页码:554 / 568
页数:15
相关论文
共 137 条
[1]   Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis [J].
Abioye, Ajibola Ibraheem ;
Bromage, Sabri ;
Fawzi, Wafaie .
BMJ GLOBAL HEALTH, 2021, 6 (01)
[2]   Aerobic exercises recommendations and specifications for patients with COVID-19: a systematic review [J].
Alawna, M. ;
Amro, M. ;
Mohamed, A. A. .
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (24) :13049-13055
[3]   A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers [J].
Allen, Aideen C. ;
Kelly, Siobhan ;
Basdeo, Sharee A. ;
Kinsella, Katie ;
Mulready, Keith J. ;
Mills, Kingston H. G. ;
Tubridy, Niall ;
Walsh, Cathal ;
Brady, Jennifer J. ;
Hutchinson, Michael ;
Fletcher, Jean M. .
MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (12) :1797-1800
[4]   Rethinking healthy eating in light of the gut microbiome [J].
Armet, Anissa M. ;
Deehan, Edward C. ;
O'Sullivan, Aidan F. ;
Mota, Joao F. ;
Field, Catherine J. ;
Prado, Carla M. ;
Lucey, Alice J. ;
Walter, Jens .
CELL HOST & MICROBE, 2022, 30 (06) :764-785
[5]   Selenium, Selenoproteins, and Immunity [J].
Avery, Joseph C. ;
Hoffmann, Peter R. .
NUTRIENTS, 2018, 10 (09)
[6]   The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation [J].
Bansal, Tarun ;
Alaniz, Robert C. ;
Wood, Thomas K. ;
Jayaraman, Arul .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (01) :228-233
[7]   Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans [J].
Beck, FWJ ;
Prasad, AS ;
Kaplan, J ;
Fitzgerald, JT ;
Brewer, GJ .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 272 (06) :E1002-E1007
[8]  
Bermon S, 2015, EXERC IMMUNOL REV, V21, P70
[9]   Microbiome-Modulated Metabolites at the Interface of Host Immunity [J].
Blacher, Eran ;
Levy, Maayan ;
Tatirovsky, Evgeny ;
Elinav, Eran .
JOURNAL OF IMMUNOLOGY, 2017, 198 (02) :572-580
[10]  
Bloomer Richard J, 2009, Lipids Health Dis, V8, P32, DOI [10.1186/1476-511X-8-36, 10.1186/1476-511X-8-32]