Progress in vaccine development for infectious diseases-a Keystone Symposia report

被引：6

作者：

Cable, Jennifer

Graham, Barney S. ^{[1
]}

Koup, Richard A. ^{[2
]}

Seder, Robert A. ^{[2
]}

Kariko, Katalin ^{[3
]}

Pardi, Norbert ^{[4
]}

Barouch, Dan H. ^{[5
]}

Sharma, Bhawna ^{[6
]}

Rauch, Susanne ^{[7
]}

Nachbagauer, Raffael ^{[8
,9
]}

Forsell, Mattias N. E. ^{[10
]}

Schotsaert, Michael ^{[8
,11
]}

Ellebedy, Ali H. ^{[12
,13
,14
]}

Lore, Karin ^{[15
,16
]}

Irvine, Darrell J. ^{[17
,18
,19
,20
,21
]}

Pilkington, Emily ^{[22
,23
]}

Tahtinen, Siri ^{[24
]}

Thompson, Elizabeth A. ^{[25
]}

Feraoun, Yanis ^{[26
]}

King, Neil P. ^{[27
,28
]}

Saunders, Kevin ^{[29
]}

Alter, Galit ^{[21
]}

Moin, Syed M. ^{[2
]}

Sliepen, Kwinten ^{[30
]}

Karlsson Hedestam, Gunilla B. ^{[31
]}

Wardemann, Hedda ^{[32
]}

Pulendran, Bali ^{[33
,34
,35
]}

Doria-Rose, Nicole A. ^{[2
]}

He, Wan-Ting ^{[20
,36
,37
]}

Juno, Jennifer A. ^{[22
]}

Ataca, Sila ^{[2
]}

Wheatley, Adam K. ^{[22
]}

McLellan, Jason S. ^{[38
]}

Walker, Laura M. ^{[39
,40
]}

Lederhofer, Julia ^{[2
]}

Lindesmith, Lisa C. ^{[41
]}

Wille, Holger ^{[42
,43
]}

Hotez, Peter J. ^{[44
,45
,46
,47
,48
,49
]}

Bekker, Linda-Gail ^{[50
]}

机构：

[1] Morehouse Sch Med, Atlanta, GA 30310 USA

[2] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD USA

[3] BioNTech SE, Mainz, Germany

[4] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Gilead Sci, Foster City, CA USA

[7] CureVac AG, Tubingen, Germany

[8] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY USA

[9] Moderna, Cambridge, MA USA

[10] Umea Univ, Dept Clin Microbiol, Umea, Sweden

[11] Icahn Sch Med Mt Sinai New York, Global Hlth & Emerging Pathogens Inst, New York, NY USA

[12] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO USA

[13] Washington Univ, Ctr Vaccines & Immun Microbial Pathogens, Sch Med, St Louis, MO USA

[14] Washington Univ, Andrew M & Jane M Bursky Ctr Human Immunol & Immu, Sch Med, St Louis, MO USA

[15] Karolinska Inst, Dept Med Solna, Stockholm, Sweden

[16] Karolinska Univ Hosp, Stockholm, Sweden

[17] MIT, Koch Inst Integrat Canc Res, Cambridge, MA USA

[18] MIT, Dept Biol Engn, Cambridge, MA USA

[19] MIT, Dept Mat Sci & Engn, Cambridge, MA USA

[20] Scripps Res Inst, Consortium HIV AIDS Vaccine Dev CHAVD, La Jolla, CA USA

[21] Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA USA

[22] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[23] Monash Univ, Dept Drug Delivery Disposit & Dynam, Monash Inst Pharmaceut Sci, Melbourne, Vic, Australia

[24] Genentech Inc, South San Francisco, CA USA

[25] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA

[26] Univ Paris Saclay, Inserm, CEA, Ctr Immunol Viral Autoimmune Hematol & Bacterial, Fontenay Aux Roses, France

[27] Univ Washington, Dept Biochem, Seattle, WA USA

[28] Univ Washington, Inst Prot Design, Seattle, WA USA

[29] Duke Univ, Human Vaccine Inst, Durham, NC USA

[30] Univ Amsterdam, Dept Med Microbiol, Amsterdam UMC, Amsterdam, Netherlands

[31] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[32] German Canc Res Ctr, Div Cell Immunol B, Heidelberg, Germany

[33] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Stanford, CA USA

[34] Stanford Univ Sch Med, Stanford Univ, Dept Pathol, Dept Microbiol & Immunol, Stanford, CA USA

[35] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA USA

[36] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA USA

[37] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA USA

[38] Univ Texas Austin, Dept Mol Biosci, Austin, TX USA

[39] Adimab LLC, Lebanon, NH USA

[40] New Hampshire & Adagio Therapeut Inc, Waltham, MA USA

[41] Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC USA

[42] Univ Alberta, Dept Biochem, Edmonton, AB, Canada

[43] Univ Alberta, Dept Biochem, Edmonton, AB, Canada

[44] Baylor Coll Med, Texas Childrens Ctr Vaccine Dev, Dept Pediat, Natl Sch Trop Med, Houston, TX USA

[45] Baylor Coll Med, Texas Childrens Ctr Vaccine Dev, Dept Mol Virol & Microbiol, Natl Sch Trop Med, Houston, TX USA

[46] Rice Univ, James A Baker III Inst Publ Policy, Houston, TX USA

[47] Baylor Univ, Dept Biol, Waco, TX USA

[48] Texas A&M Univ, Hagler Inst Adv Study, Bush Sch Govt & Publ Serv, College Stn, TX USA

[49] Texas A&M Univ, Scowcroft Inst Int Affairs, Bush Sch Govt & Publ Serv, College Stn, TX USA

[50] Univ Cape Town, Desmond Tutu HIV Ctr, Cape Town, South Africa

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2023年 / 1524卷 / 01期

关键词：

antigen design; mRNA vaccines; structural vaccinology; vaccines; vaccine delivery; vaccine hesitancy; NEUTRALIZING ANTIBODY-RESPONSES; MESSENGER-RNA VACCINES; YELLOW-FEVER VACCINE; FUSION GLYCOPROTEIN; NANOPARTICLE VACCINES; SEASONAL INFLUENZA; SYSTEMS BIOLOGY; ACCURATE DESIGN; IN-VITRO; ANTIGEN;

D O I：

10.1111/nyas.14975

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies' preparedness for future pandemics. On June 1-4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium "Progress in Vaccine Development for Infectious Diseases" to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.

引用

页码：65 / 86

页数：22

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