The State of the Art of Natural Polymer Functionalized Fe3O4 Magnetic Nanoparticle Composites for Drug Delivery Applications: A Review

被引：23

作者：

Nordin, Abu Hassan ^{[1
,2
]}

Ahmad, Zuliahani ^{[2
]}

Husna, Siti Muhamad Nur ^{[2
]}

Ilyas, Rushdan Ahmad ^{[1
,3
]}

Azemi, Ahmad Khusairi ^{[4
]}

Ismail, Noraznawati ^{[4
]}

Nordin, Muhammad Luqman ^{[5
,6
]}

Ngadi, Norzita ^{[1
]}

Siti, Nordin Hawa ^{[7
]}

Nabgan, Walid ^{[8
]}

Norfarhana, Abd Samad ^{[1
,9
]}

Azami, Mohammad Saifulddin Mohd ^{[2
]}

机构：

[1] Univ Teknol Malaysia, Fac Chem & Energy Engn, Skudai 81310, Johor, Malaysia

[2] Univ Teknol MARA UiTM, Fac Appl Sci, Arau 02600, Perlis, Malaysia

[3] Univ Teknol Malaysia UTM, Ctr Adv Composite Mat CACM, Skudai 81310, Johor, Malaysia

[4] Univ Malaysia Terengganu, Inst Marine Biotechnol, Kuala Terengganu 21030, Terengganu, Malaysia

[5] Univ Malaysia Kelantan, Fac Vet Med, Dept Clin Studies, Kota Baharu 16100, Kelantan, Malaysia

[6] Univ Malaysia Kelantan, Fac Vet Med, Ctr Nanotechnol Vet Med NanoVet, Kota Baharu 16100, Kelantan, Malaysia

[7] Univ Sultan Zainal Abidin, Fac Med, Sch Basic Med Sci, Pharmacol Unit, Kuala Terengganu 20400, Terengganu, Malaysia

[8] Univ Rovira & Virgili, Dept Engn Quim, Ave Paisos Catalans 26, Tarragona 43007, Spain

[9] Politeknik Tun Syed Nasir Syed Ismail, Dept Petrochem Engn, Pagoh Muar 84600, Johor, Malaysia

来源：

GELS | 2023年 / 9卷 / 02期

关键词：

natural polymer; magnetic nanoparticles; drug delivery; plant; animal; microbe; composites; IRON-OXIDE NANOPARTICLES; TARGETED DELIVERY; CANCER-CELLS; XANTHAN GUM; PHASE-I; ACID; MR; THERAPY; CARRIERS; GELATIN;

D O I：

10.3390/gels9020121

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Natural polymers have received a great deal of interest for their potential use in the encapsulation and transportation of pharmaceuticals and other bioactive compounds for disease treatment. In this perspective, the drug delivery systems (DDS) constructed by representative natural polymers from animals (gelatin and hyaluronic acid), plants (pectin and starch), and microbes (Xanthan gum and Dextran) are provided. In order to enhance the efficiency of polymers in DDS by delivering the medicine to the right location, reducing the medication's adverse effects on neighboring organs or tissues, and controlling the medication's release to stop the cycle of over- and under-dosing, the incorporation of Fe3O4 magnetic nanoparticles with the polymers has engaged the most consideration due to their rare characteristics, such as easy separation, superparamagnetism, and high surface area. This review is designed to report the recent progress of natural polymeric Fe3O4 magnetic nanoparticles in drug delivery applications, based on different polymers' origins.

引用

页数：29

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