Three new rotenoids from the stems of Derris elliptica and their anti-microbial activity

被引：3

作者：

Bui Thi Thu Trang ^{[1
,3
]}

Nguyen Thi Huong ^{[3
]}

Nguyen Tuan Anh ^{[3
]}

Phan Thi Thanh Huong ^{[2
]}

Nguyen Xuan Nhiem ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Grad Univ Sci & Technol, Hanoi, Vietnam

[2] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, Hanoi, Vietnam

[3] Hanoi Univ Ind, Fac Chem Technol, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 16期

关键词：

Derris elliptica; derieliptoside; rotenoid; absolute configuration; anti-microbial activity; ROOT; DERIVATIVES; SEEDS;

D O I：

10.1080/14786419.2022.2132243

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new rotenoids, named derieliptosides A-C (1-3), were isolated from the stems of Derris elliptica (Wall.) Benth. Their structures were determined by HR-ESI-MS and NMR spectroscopic methods. Absolute configurations of them were elucidated by analysis of ECD spectra in comparison with TD-DFT calculation. Compounds 1-3 inhibited the growth of fungus Candida albicans and selectively inhibited bacterial strains. Of these, compound 1 showed selective inhibition on the growth of Enterococcus faecalis (MIC: 37.5 mu M and IC50: 10.6 mu M), Staphylococcus aureus (MIC: 75 mu M and IC50: 22.7 mu M), and C. albicans (MIC: 37.5 mu M and IC50: 11.2 mu M).

引用

页码：2704 / 2711

页数：8

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