Recent insights into the effect of endoplasmic reticulum stress in the pathophysiology of intestinal ischaemia-reperfusion injury

被引:4
作者
Zhang, Jianmin [1 ]
Zhang, Xiaohui [2 ]
Liu, Yongqiang [1 ,2 ]
Shi, Yajing [1 ]
Chen, Feng [1 ]
Leng, Yufang [1 ,2 ]
机构
[1] Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Dept Anaesthesiol, Hosp 1, Lanzhou 730000, Peoples R China
关键词
Endoplasmic reticulum stress; Intestinal; Ischaemia; -reperfusion; GRP78; CHOP; Unfolded protein response; ER STRESS; ISCHEMIA/REPERFUSION INJURY; CELL-DEATH; PROTECTS; BARRIER; APOPTOSIS; PATHWAY; TISSUE; SIRT1; LUNG;
D O I
10.1016/j.bbrc.2024.149612
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intestinal ischaemia-reperfusion (I/R) injury is a surgical emergency. This condition is associated with a high mortality rate. At present, there are limited number of efficient therapeutic measures for this injury, and the prognosis is poor. Therefore, the pathophysiological mechanisms of intestinal I/R injury must be elucidated to develop a rapid and specific diagnostic and treatment protocol. Numerous studies have indicated the involvement of endoplasmic reticulum (ER) stress in the development of intestinal I/R injury. Specifically, the levels of unfolded and misfolded proteins in the ER lumen are increased due to unfolded protein response. However, persistent ER stress promotes apoptosis of intestinal mucosal epithelial cells through three signalling pathways in the ER, impairing intestinal mucosal barrier function and leading to the dysfunction of intestinal tissues and distant organ compartments. This review summarises the mechanisms of ER stress in intestinal I/R injury, diagnostic indicators, and related treatment strategies with the objective of providing novel insights into future therapies for this condition.
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页数:8
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