Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins

被引：6
作者：
Bordin, Nicola [1 ]
Lau, Andy M. [2 ]
Orengo, Christine [1 ]
机构：
[1] UCL, Inst Struct & Mol Biol, London WC1E 6BT, England
[2] UCL, Dept Comp Sci, London WC1E 6BT, England
来源：
MOLECULAR CELL | 2023年 / 83卷 / 22期
基金：
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1016/j.molcel.2023.10.039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two recent studies exploited ultra-fast structural aligners and deep-learning approaches to cluster the protein structure space in the AlphaFold Database. Barrio-Hernandez et al.1 and Durairaj et al.2 uncovered fascinating new protein functions and structural features previously unknown.
引用
收藏
页码：3950 / 3952
页数：3
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