Elucidation of the molecular mode of action of selected flavonoids (Myricetin and Bergapten) on human breast cancer MDA-MB-231 cells

被引:3
|
作者
Trivedi, Anchal [1 ]
Misra, Aparna [1 ]
Mir, Snober S. [2 ]
机构
[1] Era Univ, Eras Lucknow Med Coll & Hosp, Dept Biochem, Hardoi Rd, Lucknow 226003, Uttar Pradesh, India
[2] Integral Univ, Fac Sci, Integral Informat & Res Ctr IIRC 4 4, Dept Biosci,Mol Cell Biol Lab, Kursi Rd, Lucknow 226026, Uttar Pradesh, India
来源
ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL | 2023年 / 12卷 / 01期
关键词
Anticancer; Nutraceutical; Myricetin; Bergapten; Apoptosis;
D O I
10.54085/ap.2023.12.1.68
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Myricetin (Myr) and Bergapten (Ber) are two potential anticancer flavonoids. The current study aimed to find out whether the flavonoids Myr and Ber have breast cancer-preventive and therapeutic potential. Myr and Ber separately showed an IC50 of 50 & mu;M against MDA-MB-231 (breast cancer) cells while having no discernible impact on normal HEK-293 cells. When compared to untreated cells, Myr and Ber significantly increased the production of free radicals, induced chromatin condensation, early and late apoptosis in MDA-MB-231 cells at respective IC50 doses (50 & mu;M). Overall results indicated that Myr and Ber displayed cytotoxicity by reactive oxygen species (ROS) dependent and triggered apoptosis in breast cancer cells. Considering the results of the present study, it is possible to conclude that Myr and Ber possess significant biological activity that would help in increasing the repertoire of effective anticancer drugs with better potency.
引用
收藏
页码:295 / 302
页数:8
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