2′-fucosyllactose alone or combined with resistant starch increases circulating short-chain fatty acids in lean men and men with prediabetes and obesity

被引：3

作者：

Canfora, Emanuel E. ^{[1
]}

Vliex, Lars M. M. ^{[1
]}

Wang, Taojun ^{[2
]}

Nauta, Arjen ^{[3
]}

Bouwman, Freek G. ^{[1
]}

Holst, Jens J. ^{[4
,5
]}

Venema, Koen ^{[6
]}

Zoetendal, Erwin G. ^{[2
]}

Blaak, Ellen E. ^{[1
]}

机构：

[1] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Med Ctr, Human Biol, Maastricht, Netherlands

[2] Wageningen Univ & Res, Lab Microbiol, Wageningen, Netherlands

[3] FrieslandCampina, Amersfoort, Netherlands

[4] Univ Copenhagen, Fac Hlth & Med Sci, NovoNord Ctr Basic Metab Res, Copenhagen, Denmark

[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, Copenhagen, Denmark

[6] Maastricht Univ, Ctr Hlth Eating & Food Innovat, Campus Venlo, Venlo, Netherlands

来源：

FRONTIERS IN NUTRITION | 2023年 / 10卷

关键词：

short-chain fatty acids; human milk oligosaccharides; obesity; prediabetes; substrate metabolism; LARGE-INTESTINE; GUT MICROBIOTA; DEGRADATION; OXIDATION; TISSUE;

D O I：

10.3389/fnut.2023.1200645

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

BackgroundInfusion of short-chain fatty acids (SCFA) to the distal colon beneficially affects human substrate and energy metabolism. Here, we hypothesized that the combination of 2 & PRIME;-fucosyllactose (2 & PRIME;-FL) with resistant starch (RS) increases distal colonic SCFA production and improves metabolic parameters. MethodsIn this randomized, crossover study, 10 lean (BMI 20-24.9 kg/m(2)) and nine men with prediabetes and overweight/obesity (BMI 25-35 kg/m(2)) were supplemented with either 2 & PRIME;-FL, 2 & PRIME;-FL+RS, or placebo one day before a clinical investigation day (CID). During the CID, blood samples were collected after a overnight fast and after intake of a liquid high-fat mixed meal to determine plasma SCFA (primary outcomes). Secondary outcomes were fasting and postprandial plasma insulin, glucose, free fatty acid (FFA), glucagon-like peptide-1, and peptide YY concentrations. In addition, fecal SCFA and microbiota composition, energy expenditure and substrate oxidation (indirect calorimetry), and breath hydrogen excretion were determined. ResultsIn lean men, supplementation with 2 & PRIME;-FL increased postprandial plasma acetate (P = 0.017) and fasting H-2 excretion (P = 0.041) compared to placebo. Postprandial plasma butyrate concentration increased after 2 & PRIME;-FL and 2 & PRIME;-FL+RS as compared to placebo (P < 0.05) in lean men and men with prediabetes and overweight/obesity. Additionally, 2 & PRIME;-FL+RS decreased fasting and postprandial plasma FFA concentrations compared to placebo (P < 0.05) in lean men. ConclusionSupplementation of 2 & PRIME;-FL with/without RS the day before investigation increased systemic butyrate concentrations in lean men as well as in men with prediabetes and obesity, while acetate only increased in lean men. The combination of 2 & PRIME;-FL with RS showed a putatively beneficial metabolic effect by lowering plasma FFA in lean men, indicating a phenotype-specific effect.

引用

页数：13

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