Superiority of [11C]methionine over [18F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer

被引：23

作者：

Kubota, Yutaro ^{[1
,2
,3
]}

Sato, Toshihiko ^{[4
]}

Hozumi, Chihiro ^{[5
]}

Han, Qinghong ^{[1
]}

Aoki, Yusuke ^{[1
,2
]}

Masaki, Noriyuki ^{[1
,2
]}

Obara, Koya ^{[1
,2
]}

Tsunoda, Takuya ^{[3
]}

Hoffman, Robert M. M. ^{[1
,2
]}

机构：

[1] AntiCancer Inc, 7917 Ostrow Str, San Diego, CA 92111 USA

[2] Univ Calif San Diego, Dept Surg, San Diego, CA 92037 USA

[3] Showa Univ, Dept Med Oncol, Div Internal Med, Sch Med, Tokyo 1428666, Japan

[4] Utsunomiya Cent Clin, Tochigi 3210112, Japan

[5] Anticanc Japan Inc, Chiba 2701505, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 03期

关键词：

methionine; PET; methionine addiction; Hoffman effect; lung cancer; bladder cancer; rectal cancer; renal-cell carcinoma; granuloma; POSITRON-EMISSION-TOMOGRAPHY; CELLS; DEPENDENCE; CARBON-11-METHIONINE; TRANSMETHYLATION; C-11-METHIONINE; CARCINOMA; F-18-FDG; OCCURS; RATES;

D O I：

10.3390/ijms24031935

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Positron emission tomography (PET) is widely used to detect cancers. The usual isotope for PET imaging of cancer is [F-18]deoxyglucose. The premise of using [F-18]deoxyglucose is that cancers are addicted to glucose (The Warburg effect). However, cancers are more severely addicted to methionine (The Hoffman effect). [C-11]methionine PET (MET-PET) has been effectively used for the detection of glioblastoma and other cancers in the brain, and in comparison, MET-PET has been shown to be more sensitive and accurate than [F-18]deoxyglucose PET (FDG-PET). However, MET-PET has been limited to cancers in the brain. The present report describes the first applications of MET-PET to cancers of multiple organs, including rectal, bladder, lung, and kidney. The results in each case show that MET-PET is superior to FDG-PET due to the methionine addiction of cancer and suggest that the broad application of MET-PET should be undertaken for cancer detection.

引用

页数：7

共 32 条

[1] Clinical role of positron emission tomography in oncology [J].