Introduction of an Efficient Protocol for the Synthesis of Some of the Pyrimidine Derivatives under Solvent-Free Conditions

被引：1

作者：

Takbiri, Sam ^{[1
]}

Goil-Jolodar, Omid ^{[2
]}

Shirini, Farhad ^{[2
]}

Hafshejani, Mahmood Tavakoli ^{[1
]}

机构：

[1] Univ Isfahan, Dept Chem, Catalysis Div, Esfahan, Iran

[2] Univ Guilan, Coll Sci, Dept Chem, Rasht, Iran

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 06期

关键词：

Basic ionic liquid catalyst; multicomponent reactions; pyrimidine; solvent-free conditions; IONIC LIQUID; ACID; CONDENSATION; CATALYST; QUINAZOLINE; LIBRARY; FACILE;

D O I：

10.1080/10406638.2022.2103577

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various pyrimidine derivatives were synthesized via one-pot three-component condensation of aromatic aldehydes, malononitrile, and multiple amines using 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) hydroxide as a basic ionic liquid catalyst under solvent-free conditions. The advantages of this method are the simplicity of the procedure, short reaction times, high yields, no-column chromatographic separation, commercial availability of the preliminary materials, and reusability of the catalyst.

引用

页码：5536 / 5544

页数：9

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