Comparing hs-CRP and MPO Biomarkers of Subclinical Atherosclerosis in Metabolic Syndrome Patients

被引:0
作者
Beautlin, Abishkauf Jenish [1 ]
Govindaraj, Ashok [1 ]
Devi, Durga [1 ]
Ilangovan, Gurubharath [2 ]
Lakshmi, Divya [1 ]
机构
[1] Chettinad Acad Res & Educ, Dept Cardiol, Kelambakkam, Tamil Nadu, India
[2] Chettinad Acad Res & Educ, Dept Radiol, Kelambakkam, Tamil Nadu, India
关键词
Flow Mediated Vasodilatation; Carotid Intima Medial Thickness; Metabolic Syndrome; hs-CRP; Myeloperoxidase; C-REACTIVE PROTEIN; MYELOPEROXIDASE-CATALYZED OXIDATION; CORONARY-ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; HYPOCHLOROUS ACID; PROGNOSTIC VALUE; HEART-DISEASE; RISK; EVENTS; INFLAMMATION;
D O I
10.22207/JPAM.17.4.12
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cardiovascular disorders have been linked to myeloperoxidase, an enzyme generated from leukocytes. MPO creates an antibacterial system and has been many correlations between MPO, hs-CRP and cardiovascular disease. The present study has aimed to assess MPO, hs-CRP and subclinical atherosclerosis in metabolic syndrome patients by using FMD and CIMT parameters. 75 metabolic syndrome affected patients had defined as per the criteria of IDF (International Diabetes Federation) which had been in this study. In addition, ultrasound doppler had been employed for determining the carotid intima medial thickness for both right and left (left and right CIMT) and brachial artery FMD. By employing the Immunoassay MPO and hs-CRP ultrasensitive ELISA kit, the concentration of MPO and hs-CRP is measured. A positive link between MPO with CIMT right and left (r value of right CIMT=0.723, p <0.05 and left CIMT r=0.712, p<0.01), hs-CRP with CIMT right and left (r value of right CIMT=0.613, p<0.05and left CIMT r=0.64, p<0.01)and a significant inverse correlation between MPO with FMD (r=-0.319,p<0.05), hs-CRP with FMD (r=-0.304,p<0.01) in metabolic syndrome patients. Serum MPO and hs-CRP is positively linked with subclinical atherosclerosis in metabolic syndrome patients. According to this finding, understanding the mechanism behind the risk factors for cardiovascular disease can be aided by the development of new molecular markers for metabolic syndrome and subclinical atherosclerosis.
引用
收藏
页码:2157 / 2164
页数:8
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