Fabrication of targeted gold nanoparticle as potential contrast agent in molecular CT imaging

被引：19

作者：

Malekzadeh, Reza ^{[1
,2
]}

Ghorbani, Marjan ^{[3
]}

Faghani, Parsa ^{[4
]}

Abdollahi, Behnaz Babaye ^{[1
]}

Mortezazadeh, Tohid ^{[1
]}

Farhood, Bagher ^{[5
]}

机构：

[1] Tabriz Univ Med Sci, Sch Med, Dept Med Phys, Tabriz, Iran

[2] Tabriz Univ Med Sci, Med Radiat Sci Res Team, Tabriz, Iran

[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[4] Shiraz Univ Med Sci, Sch Med, Dept Med Phys, Shiraz, Iran

[5] Kashan Univ Med Sci, Fac Paramed Sci, Dept Med Phys & Radiol, Kashan, Iran

来源：

JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES | 2023年 / 16卷 / 01期

关键词：

Contrast agent; Molecular CT imaging; Trastuzumab; Gold nanoparticles; Cancer; BIODISTRIBUTION; IODINE; MRI;

D O I：

10.1016/j.jrras.2022.100490

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Au NPs) through polyethylene glycol (PEG) linking for targeted molecular computed tomography (CT) imaging was developed. The prepared TZ-PEG-Fe3O4@Au NPs were fully characterized and cytocompatibility, X-ray attenuation measurement, and in vitro cell targeting ability were analyzed. The findings showed that the synthesized NPs, with a size of less than 100 nm, were non-toxic at specific concentration ranges, and exhibit better X-ray attenuation intensity than iodine-based contrast agents at the same concentration. The created targeted NPs can be employed as a contrast agent for molecular targeted CT imaging of cancer cells expressing the human epidermal growth factor receptor 2 (HER-2).

引用

页数：9

共 30 条

[1] Synthesis and characterization of actively HER-2 Targeted Fe3O4@Au nanoparticles for molecular radiosensitization of breast cancer [J].

Abdollahi, Behnaz Babaye ;

Ghorbani, Marjan ;

Hamishehkar, Hamed ;

Malekzadeh, Reza ;

Farajollahi, Ali Reza .

BIOIMPACTS, 2023, 13 (01) :17-29

[2] Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review [J].

Abdollahi, Behnaz Babaye ;

Malekzadeh, Reza ;

Azar, Fatemeh Pournaghi ;

Salehnia, Fatemeh ;

Naseri, Ali Reza ;

Ghorbani, Marjan ;

Hamishehkar, Hamed ;

Farajollahi, Ali Reza .

ADVANCED PHARMACEUTICAL BULLETIN, 2021, 11 (02) :212-223

[3] Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment [J].

Akrami, Mohammad ;

Khoobi, Mehdi ;

Khalilvand-Sedagheh, Masoud ;

Haririan, Ismaeil ;

Bahador, Abbas ;

Faramarzi, Mohammad Ali ;

Rezaei, Shahla ;

Javar, Hamid Akbari ;

Salehi, Fahimeh ;

Ardestanie, Sussan Kabudanian ;

Shafiee, Abbas .

RSC ADVANCES, 2015, 5 (107) :88096-88107

[4] Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE [J].

Anderson, N. G. ;

Butler, A. P. ;

Scott, N. J. A. ;

Cook, N. J. ;

Butzer, J. S. ;

Schleich, N. ;

Firsching, M. ;

Grasset, R. ;

de Ruiter, N. ;

Campbell, M. ;

Butler, P. H. .

EUROPEAN RADIOLOGY, 2010, 20 (09) :2126-2134

[5] Adsorption of Cr(VI) onto PEI immobilized acrylate-based magnetic beads: Isotherms, kinetics and thermodynamics study [J].

Bayramoglu, Guelay ;

Arica, M. Yakup .

CHEMICAL ENGINEERING JOURNAL, 2008, 139 (01) :20-28

[6] Gold-coated iron nanoparticles:: a novel magnetic resonance agent for T1 and T2 weighted imaging [J].

Cho, SJ ;

Jarrett, BR ;

Louie, AY ;

Kauzlarich, SM .

NANOTECHNOLOGY, 2006, 17 (03) :640-644

[7] In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT [J].

Clark, Darin P. ;

Ghaghada, Ketan ;

Moding, Everett J. ;

Kirsch, David G. ;

Badea, Cristian T. .

PHYSICS IN MEDICINE AND BIOLOGY, 2013, 58 (06) :1683-1704

[8]

Cole LE, 2015, NANOMEDICINE-UK, V10, P321, DOI [10.2217/NNM.14.171, 10.2217/nnm.14.171]

[9] Excellent relaxivity and X-ray attenuation combo properties of Fe3O4@Au CSNPs produced via Rapid sonochemical synthesis for MRI and CT imaging [J].

Dheyab, Mohammed Ali ;

Aziz, Azlan Abdul ;

Jameel, Mahmood S. ;

Abu Noqta, Osama ;

Khaniabadi, Pegah Moradi ;

Mehrdel, Baharak .

MATERIALS TODAY COMMUNICATIONS, 2020, 25

[10] New technologies for human cancer imaging [J].

Frangioni, John V. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (24) :4012-4021

← 1 2 3 →