Comprehensive review on the Bis-heterocyclic compounds and their anticancer efficacy

被引：76

作者：

Al-Jumaili, Mohammed Hadi Ali ^{[1
]}

Hamad, Anas Abdullah ^{[2
]}

Hashem, Heba E. ^{[3
]}

Hussein, Abdulhakeem D. ^{[4
]}

Muhaidi, Mohammed J. ^{[5
]}

Ahmed, Mohammad Abdaljabbar ^{[6
]}

Albanaa, Ali Hussein Alwan ^{[7
]}

Siddique, Farhan ^{[7
]}

Bakr, Ekhlas Aziz ^{[8
]}

机构：

[1] Dijlah Univ Coll, Dept Anesthesia Tech, Baghdad 10022, Al Doura, Iraq

[2] Al Maarif Univ Coll, Dept Med Lab Tech, Al Anbar 31001, Ramadi, Iraq

[3] Ain Shams Univ, Fac Women, Dept Chem, Cairo 11757, Egypt

[4] Univ Fallujah, Coll Sci, Dept Chem, Al Anbar, Iraq

[5] Univ Fallujah, Coll Appl Sci, Al Anbar, Iraq

[6] Dijlah Univ Coll, Dept Med Lab Tech, Baghdad, Iraq

[7] Bahauddian Zakariya Univ, Fac Pharm, Dept Pharmaceut Chem, Multan 60800, Pakistan

[8] Al Anbar Adm, Minist Educ, Al Anbar, Iraq

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1271卷

关键词：

Bis-heterocyclic compounds; Anticancer activities; Physicochemical properties; Anticancer drugs; Structure activity relationship (SAR); CANCER; DERIVATIVES;

D O I：

10.1016/j.molstruc.2022.133970

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Heterocyclic compounds are one of the largest family of organic compounds with broad range of appli-cations in medicinal chemistry and agrochemicals product. Bis-heterocycle and their families have had a significant development of new anticancer drugs according to the literature data published in recent years. Bis-heterocyclic compounds are present in various pharmaceuticals with unique physicochemical properties and have been confirmed as major pillars of medicinal chemistry. Anticancer research has been focused on these molecules' versatility and dynamic core structure. The presented review aims to summarize different bis-heterocyclic active compounds and their beneficial functions as drug targets in cancer therapy and chemoprevention.(c) 2022 Elsevier B.V. All rights reserved.

引用

页数：16

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