Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

被引：0

作者：

Sedenkova, Kseniya N. ^{[1
]}

Kositov, Sergey V. ^{[1
]}

Zverev, Denis V. ^{[1
]}

Radchenko, Eugene V. ^{[1
]}

Grishin, Yuri K. ^{[1
]}

Gabrel'yan, Alexey V. ^{[2
]}

Zamoyski, Vladimir L. ^{[2
]}

Grigoriev, Vladimir V. ^{[1
,2
]}

Averina, Elena B. ^{[1
]}

Palyulin, Vladimir A. ^{[1
]}

机构：

[1] M V Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia

[2] Russian Acad Sci, Inst Physiol Act Cpds, Fed Res Ctr Problems Chem Phys & Med Chem, Moscow 142432, Russia

来源：

MENDELEEV COMMUNICATIONS | 2024年 / 34卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

pyrimidines; aromatic nucleophilic substitution; AMPA receptor; allosteric modulators; bivalent ligands; GLUTAMATE RECEPTORS; FORCE-FIELD; LIGANDS; DESIGN;

D O I：

10.1016/j.mencom.2024.01.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new bis(pyrimidines) with p-hydroquinone linker was prepared and evaluated as AMPA receptor modulators. Both positive and negative modulators were found among the investigated compounds.

引用

页码：8 / 10

页数：3

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