Curcumin I-SMA nanomicelles as promising therapeutic tool to tackle bacterial infections

被引：6

作者：

Virzi, Nicola F. ^{[1
]}

Fallica, Antonino N. ^{[1
]}

Romeo, Giuseppe ^{[1
]}

Greish, Khaled ^{[2
]}

Alghamdi, Maha Ali ^{[2
]}

Patane, Salvatore ^{[3
]}

Mazzaglia, Antonino ^{[4
]}

Shahid, Mohammad ^{[5
]}

Pittala, Valeria ^{[1
,2
]}

机构：

[1] Univ Catania, Dept Drug & Hlth Sci, Viale A Doria 6, I-95125 Catania, Italy

[2] Arabian Gulf Univ, Dept Mol Med, Manama 329, Bahrain

[3] Univ Messina, Dept Math & Comp Sci, Phys Sci & Earth Sci, Vle F Stagno DAlcontres 31, I-98166 Messina, Italy

[4] Univ Messina, Natl Council Res Inst Study Nanostruct Mat CNR ISM, Dept Chem Biol Pharmaceut & Environm Sci, Natl Council Res,Inst Study Nanostruct Mat CNR ISM, Vle F Stagno dAlcontres 31, I-98166 Messina, Italy

[5] Arabian Gulf Univ, Dept Microbiol & Immunol, Manama 329, Bahrain

来源：

RSC ADVANCES | 2023年 / 13卷 / 44期

关键词：

DOXORUBICIN; RESISTANCE; MICELLES; DRUG;

D O I：

10.1039/d3ra04885c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Renewed interest towards natural substances has been pushed by the widespread diffusion of antibiotic resistance. Curcumin I is the most active and effective constituent of curcuminoids extracted from Curcuma longa and, among other beneficial effects, attracted attention for its antimicrobial potential. Since the poor pharmacokinetic profile hinders its efficient utilization, in the present paper, we report encapsulation of curcumin I in poly(styrene-co-maleic acid) (SMA-CUR) providing a nanomicellar system with improved aqueous solubility and bioavailability. SMA-CUR was characterized by means of size, zeta potential, polydispersity index, atomic force microscopy (AFM), drug release studies, spectroscopic properties and stability. SMA-CUR nanoformulation displayed exciting antimicrobial properties compared to free curcumin I towards Gram-positive and Gram-negative clinical isolates. Renewed interest towards natural substances has been pushed by the widespread diffusion of antibiotic resistance.

引用

页码：31059 / 31066

页数：8

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