Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: A multicenter retrospective case-control study

被引：13

作者：

Johnson, Hadley ^{[1
,2
]}

Aquino, Marcella R. ^{[3
,4
]}

Snyder, Alan ^{[5
]}

Collis, Reid W. ^{[6
]}

Franca, Katlein ^{[7
]}

Goldenberg, Alina ^{[8
,9
]}

Sui, Jennifer Y. ^{[10
,11
]}

Eichenfield, Dawn Z. ^{[10
,11
]}

Kozy, Brittany J. ^{[12
]}

Chen, Jennifer K. ^{[13
]}

Shope, Chelsea ^{[5
]}

Goldminz, Ari M. ^{[14
]}

Yu, JiaDe ^{[2
,15
]}

机构：

[1] Univ Minnesota, Sch Med, Minneapolis, MN USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Dermatol, Boston, MA USA

[3] Hasbro Childrens Hosp, Dept Pediat, Div Allergy & Immunol, Providence, RI USA

[4] Brown Univ, Dept Pediat, Div Allergy & Immunol, Warren Alpert Med Sch, Providence, RI USA

[5] Med Univ South Carolina, Dept Dermatol, Charleston, SC USA

[6] Washington Univ, Dept Dermatol, Sch Med, St Louis, MO USA

[7] Univ Miami, Dr Frost Dept Dermatol & Cutaneous Surg, Miller Sch Med, Miami, FL USA

[8] Dermatologist Med Grp North Cty, San Diego, CA USA

[9] Univ Calif San Diego, Dept Med, San Diego, CA USA

[10] Rady Childrens Hosp, Div Pediat & Adolescent Dermatol, San Diego, CA USA

[11] Univ Calif San Diego, Dept Dermatol, La Jolla, CA USA

[12] Nationwide Childrens Hosp, Div Pediat Dermatol, Columbus, OH USA

[13] Stanford Univ Sch Med, Dept Dermatol, Dept Dermatol, Redwood City, CA USA

[14] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Chestnut Hill, MA USA

[15] Massachusetts Gen Hosp, Dept Dermatol, 50 Staniford St,Suite 200, Boston, MA 02114 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2023年 / 89卷 / 05期

关键词：

allergic contact dermatitis; atopic dermatitis; children; patch testing; pediatric;

D O I：

10.1016/j.jaad.2023.06.048

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: As both allergic contact dermatitis and atopic dermatitis (AD) have similar clinical presentations and are characterized by spongiotic dermatitis on skin biopsy, many children with AD are not referred for patch testing and allergic contact dermatitis is underdiagnosed. Objective: To provide updated prevalence data of common contact allergens in children with and without AD. Methods: This is a retrospective case-control study using the Pediatric Allergic Contact Dermatitis Registry from 2018 to 2022. Results: A total of 912 children were included (615 with AD and 297 without AD). Children with AD were more likely to have a longer history of dermatitis (4.1 vs 1.6 years, P \ .0001), have seen more providers (2.3 vs 2.1, P = .003), have greater than 1 positive patch test (PPT) result (P = .005), have a greater number of PPT results overall (2.3 vs 1.9, P = .012), and have a more generalized distribution of dermatitis (P = .001). PPT to bacitracin (P = .030), carba mix (P = .025), and cocamidopropyl betaine (P = .0007) were significantly increased in children with AD compared to those without AD. Limitations: Technical variation between providers and potential for misclassification, selection, and recall biases. Conclusion: Children with AD are significantly more likely to have PPT reactions and should be referred for evaluation of allergic contact dermatitis and obtain patch testing. ( J Am Acad Dermatol 2023;89:1007-14.)

引用

页码：1007 / 1014

页数：8

共 10 条

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