CD11a regulates hematopoietic stem and progenitor cells

被引：2

作者：

Hou, Lifei ^{[1
,2
,3
,4
]}

Yuki, Koichi ^{[1
,2
,3
,4
]}

机构：

[1] Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Cardiac Anesthesia Div, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Anaesthesia, Boston, MA 02115 USA

[3] Harvard Med Sch, Dept Immunol, Boston, MA 02115 USA

[4] Broad Inst Harvard & Massachusetts Inst Technol MI, Cambridge, MA 02142 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

CD11a; sepsis; hematopoietic stem and progenitor cells (HPSCs); il-27; inflammation; GENE-EXPRESSION; BONE-MARROW; INTEGRINS; IL-27; ADHESION; BIOLOGY;

D O I：

10.3389/fimmu.2023.1219953

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Integrin alpha L beta 2 (CD11a/CD18, CD11a) is a critical leukocyte adhesion molecule in leukocyte arrest and immunological synapse formation. However, its role in the bone marrow has not been investigated in depth. Here we showed that CD11a was expressed on all subsets of hematopoietic stem and progenitor cells (HPSCs). CD11a deficiency enhanced HSPCs activity under lipopolysaccharide (LPS) stimulation as demonstrated by a higher HSPC cell count along with an increase in cell proliferation. However, our mixed chimera experiment did not support that this phenotype was driven in a cell-intrinsic manner. Rather we found that the production of IL-27, a major cytokine that drives HSPC proliferation, was significantly upregulated both in vivo and in vitro. This adds a novel role of CD11a biology.

引用

页数：7

共 31 条

[1] Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis [J].

Abdalla, Abualgasim Elgaili ;

Li, Qiming ;

Xie, Longxiang ;

Xie, Jianping .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2015, 11 (02) :168-175

[2] Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3 [J].

Bosmann, Markus ;

Russkamp, Norman F. ;

Strobl, Birgit ;

Roewe, Julian ;

Balouzian, Liza ;

Pache, Florence ;

Radsak, Markus P. ;

van Rooijen, Nico ;

Zetoune, Firas S. ;

Sarma, J. Vidya ;

Nunez, Gabriel ;

Mueller, Mathias ;

Murray, Peter J. ;

Ward, Peter A. .

JOURNAL OF IMMUNOLOGY, 2014, 193 (11) :5668-5677

[3] Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis [J].

Bullard, Daniel C. ;

Hu, Xianzhen ;

Schoeb, Trenton R. ;

Collins, Robert G. ;

Beaudet, Arthur L. ;

Barnum, Scott R. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (02) :851-857

[4] Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis [J].

Cardoso, Ana ;

Martins, Ana Catarina ;

Maceiras, Ana Raquel ;

Liu, Wei ;

Castro, Isabel ;

Castro, Antonio G. ;

Bandeira, Antonio ;

Di Santo, James P. ;

Cumano, Ana ;

Li, Yan ;

Vieira, Paulo ;

Saraiva, Margarida .

CELL REPORTS, 2021, 37 (04)

[5] Adhesion receptors on haematopoietic progenitor cells [J].

Chan, JYH ;

Watt, SM .

BRITISH JOURNAL OF HAEMATOLOGY, 2001, 112 (03) :541-557

[6] Upregulation of CD11A on Hematopoietic Stem Cells Denotes the Loss of Long-Term Reconstitution Potential [J].

Fathman, John W. ;

Fernhoff, Nathaniel B. ;

Seita, Jun ;

Chao, Connie ;

Scarfone, Vanessa M. ;

Weissman, Irving L. ;

Inlay, Matthew A. .

STEM CELL REPORTS, 2014, 3 (05) :707-715

[7] Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis [J].

Furusawa, Jun-ichi ;

Mizoguchi, Izuru ;

Chiba, Yukino ;

Hisada, Masayuki ;

Kobayashi, Fumie ;

Yoshida, Hiroki ;

Nakae, Susumu ;

Tsuchida, Akihiko ;

Matsumoto, Tetsuya ;

Ema, Hideo ;

Mizuguchi, Junichiro ;

Yoshimoto, Takayuki .

PLOS PATHOGENS, 2016, 12 (03)

[8] Midkine, a middle manager of β2 integrins [J].

Herter, Jan M. ;

Mayadas, Tanya N. .

BLOOD, 2014, 123 (12) :1777-1779

[9] CD11c regulates late-stage T cell development in the thymus [J].

Hou, Lifei ;

Yuki, Koichi .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[10] CD11c regulates neutrophil maturation [J].

Hou, Lifei ;

Voit, Richard A. ;

Shibamura-Fujiogi, Miho ;

Koutsogiannaki, Sophia ;

Li, Yunan ;

Chen, Yue ;

Luo, Hongbo ;

Sankaran, Vijay G. ;

Yuki, Koichi .

BLOOD ADVANCES, 2023, 7 (07) :1312-1325

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