An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

被引：2

作者：

Murphy, Ciara ^{[1
,2
]}

Gornes Pons, Gloria ^{[2
,3
]}

Keogh, Anna ^{[2
,4
]}

Ryan, Lisa ^{[1
]}

Mccarra, Lorraine ^{[1
]}

Jose, Chris Maria ^{[5
]}

Kesar, Shagun ^{[5
]}

Nicholson, Siobhan ^{[1
]}

Fitzmaurice, Gerard J. ^{[6
]}

Ryan, Ronan ^{[6
]}

Young, Vincent ^{[6
]}

Cuffe, Sinead ^{[7
]}

Finn, Stephen P. ^{[1
,2
,4
]}

Gray, Steven G. ^{[2
,8
,9
]}

机构：

[1] St James Hosp, Dept Histopathol, Labmed Directorate, Dublin D08 NHY1, Ireland

[2] St James Hosp, Cent Pathol Lab, Trinity St Jamess Canc Inst TSJCI, Thorac Oncol Res Grp, Dublin D08 RX0X, Ireland

[3] Univ Barcelona, Fac Biol, Barcelona 08025, Spain

[4] Trinity Coll Dublin, Dept Histopathol & Morbid Anat, Dublin D02 PN40, Ireland

[5] Trinity Coll Dublin, Sch Med, Dublin D02 PN40, Ireland

[6] St James Hosp, Surg Anaesthesia & Crit Care Directorate, Dublin D08 NHY1, Ireland

[7] St James Hosp, HOPE Directorate, Dublin D08 NHY1, Ireland

[8] Trinity Coll Dublin, Dept Clin Med, Dublin D02 PN40, Ireland

[9] Technol Univ Dublin, Sch Biol & Hlth Sci, Dublin D07 XT95, Ireland

来源：

BIOMEDICINES | 2023年 / 11卷 / 09期

关键词：

non-small cell lung cancer; JADE2; overexpression; prognosis; mutation; tumor mutational burden; tumor-infiltrating immune cells; TUMOR MUTATIONAL BURDEN; TNM CLASSIFICATION; PARTNER JADE-1; 8TH EDITION; SUPPRESSOR; EXPRESSION; CHROMATIN; HALLMARKS; HBO1; ASSOCIATIONS;

D O I：

10.3390/biomedicines11092576

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particular JADE2 have not been studied in any great detail in cancer. Using a series of standard biological and bioinformatics approaches we investigated JADE2 expression in surgically resected non-small cell lung cancer (NSCLC) for both mRNA and protein to examine for correlations between JADE2 expression and overall survival. Additional correlations were identified using bioinformatic analyses on multiple online datasets. Our analysis demonstrates that JADE2 expression is significantly altered in NSCLC. High expression of JADE2 is associated with a better 5-year overall survival. Links between JADE2 mRNA expression and a number of mutated genes were identified, and associations between JADE2 expression and tumor mutational burden and immune cell infiltration were explored. Potential new drugs that can target JADE2 were identified. The results of this biomarker-driven study suggest that JADE2 may have potential clinical utility in the diagnosis, prognosis and stratification of patients into various therapeutically targetable options.

引用

页数：25

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