Association of selenium profile with neutralizing antibody response to inactivated SARS-CoV-2 vaccination

被引:0
作者
Gao, Sikang [1 ]
Ren, Na [2 ]
Sun, Taoping [2 ]
Nie, Qi [3 ]
Liu, Sitian [3 ]
Geng, Xuyang [2 ]
Deng, Yao [2 ]
Lin, Zefang [2 ]
Liu, Yu [2 ]
Zhou, Li [3 ,4 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China
[2] Jinan Univ, Zhuhai Hosp, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr,Guangdong Prov Key Lab Tumor, Zhuhai, Peoples R China
[3] Wuhan Univ Sci & Technol, Acad Nutr & Hlth, Med Coll, Sch Publ Hlth,Dept Nutr Hyg & Toxicol, Wuhan 430065, Peoples R China
[4] Wuhan Univ Sci & Technol, Med Coll, Sch Publ Hlth, Dept Nutr Hyg & Toxicol, 10 Huangjiahu Rd, Wuhan 430065, Peoples R China
基金
中国国家自然科学基金;
关键词
Selenium profile; SARS-CoV-2; Vaccine; Neutralizing antibody; COVID-19; VACCINE; IMMUNE FUNCTION; T-CELL; SUPPLEMENTATION; BNT162B2;
D O I
10.1016/j.jtemb.2023.127295
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Selenium profile has been related with humoral immune response after vaccination, but evidence with regard to inactivated SARS-CoV-2 vaccine is lacking.Objective: The current study aimed to examine the relationship between selenium profile and neutralizing antibody response to inactivated SARS-CoV-2 vaccine.Methods: Plasma selenium and selenoprotein P concentrations, neutralizing antibody against the wild-type and Omicron variant were measured at baseline and at 14 days, 98 days after the third dose of inactivated SARS-CoV2 vaccine.Results: Neutralizing antibody against the wild-type and Omicron variant increased significantly after the third vaccination dose. Both higher plasma selenium and selenoprotein P were associated with increased neutralizing antibody against the wild-type strain at baseline. Moreover, higher plasma selenoprotein P was associated with increased neutralizing antibody against Omicron variant at baseline. However, nonsignificant association were observed after the third vaccine dose.Conclusion: Higher selenium profile was associated with neutralizing antibody response before the third dose of inactivated SARS-CoV-2 vaccine, but not after the third dose. Further prospective cohort studies are warranted to confirm our findings.
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页数:6
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