Sex-specific relationships between prenatal exposure to metal mixtures and birth weight in a Chinese birth cohort

被引:6
作者
Wu, Ying [1 ]
Zeng, Fulin [2 ]
Li, Jinhui [3 ]
Jiang, Yukang [4 ,5 ]
Zhao, Shi [6 ,7 ]
Knibbs, Luke D. [8 ]
Zhang, Xiaojun [2 ]
Wang, Yiding [2 ]
Zhang, Qianqian [9 ]
Wang, Qiong [9 ]
Hu, Qiansheng [9 ]
Guo, Xiaobo [4 ,5 ]
Chen, Yumeng [10 ]
Cao, Ganxiang [10 ]
Wang, Jing [11 ]
Yang, Xingfen [2 ]
Wang, Xueqin [12 ]
Liu, Tao [13 ,14 ]
Zhang, Bo [2 ,15 ]
机构
[1] Southern Med Univ, Sch Publ Hlth, Dept Biostat, Guangzhou, Guangdong, Peoples R China
[2] Southern Med Univ, Food Safety & Hlth Res Ctr, Sch Publ Hlth, Guangdong Hongkong Macao Joint Lab Contaminants Ex, Guangzhou, Guangdong, Peoples R China
[3] Stanford Univ, Dept Urol, Med Ctr, Stanford, CA USA
[4] Sun Yat Sen Univ, Sch Math, Guangzhou, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Southern China Ctr Stat Sci, Guangzhou, Guangdong, Peoples R China
[6] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
[7] Chinese Univ Hong Kong CUHK Shenzhen Res Inst, Shenzhen, Guangdong, Peoples R China
[8] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia
[9] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China
[10] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China
[11] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China
[12] Univ Sci & Technol China, Int Inst Finance, Sch Management, Dept Stat & Finance, Hefei, Anhui, Peoples R China
[13] Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou, Guangdong, Peoples R China
[14] Jinan Univ, Dis Control & Prevent Inst, Guangzhou, Guangdong, Peoples R China
[15] Southern Med Univ, Food Safety & Hlth Res Ctr, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Metal mixture; Pregnancy; Sex heterogeneity; Birth weight; Bayesian Kernel Machine Regression; CADMIUM EXPOSURE; MATERNAL OBESITY; CORD BLOOD; ASSOCIATION; DISEASE; HEALTH; PREGNANCY; RESPONSES; THALLIUM; NEWBORNS;
D O I
10.1016/j.ecoenv.2023.115158
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Birth weight is an indicator linking intrauterine environmental exposures to later-life diseases, and intrauterine metal exposure may affect birth weight in a sex-specific manner. We investigated sex-specific associations be-tween prenatal exposure to metal mixtures and birth weight in a Chinese birth cohort. The birth weight of 1296 boys and 1098 girls were recorded, and 10 metals in maternal urine samples collected during pregnancy were measured using inductively coupled plasma mass spectrometry. Bayesian Kernel Machine Regression was used to estimate the association of individual metals or metal mixtures and birth weight for gestational age (BW for GA). The model showed a sex-specific relationship between prenatal exposure to metal mixtures and BW for GA with a significant negative association in girls and a non-significant positive association in boys. Cadmium (Cd) and nickel (Ni) were positively and negatively associated with BW for GA in girls, respectively. Moreover, increasing thallium (Tl) concentration lowered the positive association between Cd and BW for GA and enhanced the negative association between Ni and BW for GA in girls. When exposure to other metals increased, the positive association with Cd diminished, whereas the negative association with Ni or Tl increased. Our findings provide evidence supporting the complex effects of intrauterine exposure to metal mixtures on the birth weight of girls and further highlight the sex heterogeneity in fetal development influenced by intrauterine environmental factors.
引用
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页数:10
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