Phospholipid-Coated Boronic Oxide Nanoparticles as Boron Agents for Boron Neutron Capture Therapy

被引：3

作者：

Kawasaki, Riku ^{[1
]}

Hirano, Hidetoshi ^{[1
]}

Yamana, Keita ^{[1
]}

Oshige, Ayano ^{[1
]}

Nishimura, Kotaro ^{[1
]}

Kono, Nanami ^{[1
]}

Sanada, Yu ^{[2
]}

Bando, Kaori ^{[3
]}

Tabata, Anri ^{[3
]}

Yasukawa, Naoki ^{[3
]}

Azuma, Hideki ^{[3
]}

Takata, Takushi ^{[2
]}

Sakurai, Yoshinori ^{[2
]}

Tanaka, Hiroki ^{[2
]}

Suzuki, Minoru ^{[2
]}

Tarutani, Naoki ^{[1
]}

Katagiri, Kiyofumi ^{[1
]}

Nagasaki, Takeshi ^{[3
]}

Ikeda, Atsushi ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Adv Sci & Engn, Program Appl Chem, 1-4-1 Kagamiyama, Higashihiroshima 7398527, Japan

[2] Kyoto Univ, Inst Integrated Radiat & Nucl Sci, Kumatori Cho, Osaka 5900494, Japan

[3] Osaka Metropolitan Univ, Grad Sch Engn, Dept Chem & Bioengn, 3-3-138 Sugimoto,Sumiyoshi Ku, Osaka 5588585, Japan

来源：

CHEMBIOCHEM | 2023年 / 24卷 / 15期

基金：

日本学术振兴会;

关键词：

boron neutron capture therapy; drug delivery systems; lipid nanoparticles; organic-inorganic hybrid nanomaterials; DNA-DAMAGE; ENDOCYTOSIS; DELIVERY; CANCER; CELLS; BSH;

D O I：

10.1002/cbic.202300186

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high-efficiency cell destruction. Herein, we report phospholipid-coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation-induced growth.

引用

页数：5

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