CCAT 1-A Pivotal Oncogenic Long Non-Coding RNA in Colorectal Cancer

被引：16

作者：

Liau, Xiew Leng ^{[1
]}

Salvamani, Shamala ^{[1
]}

Gunasekaran, Baskaran ^{[2
]}

Chellappan, Dinesh Kumar ^{[3
]}

Rhodes, Anthony ^{[4
]}

Ulaganathan, Vaidehi ^{[2
]}

Tiong, Yee Lian ^{[2
]}

机构：

[1] Int Med Univ, Sch Hlth Sci, Div Appl Biomed Sci & Biotechnol, Kuala Lumpur, Malaysia

[2] UCSI Univ, Fac Appl Sci, Dept Biotechnol, Kuala Lumpur, Malaysia

[3] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia

[4] Univ Malaya, Fac Med, Dept Pathol, Kuala Lumpur, Malaysia

来源：

BRITISH JOURNAL OF BIOMEDICAL SCIENCE | 2023年 / 80卷

关键词：

biomarker; long non-coding RNA; colorectal cancer; CCAT; 1; c-MYC; CELL-PROLIFERATION; RANGE INTERACTION; POOR-PROGNOSIS; N-CADHERIN; MYC; 8Q24; TRANSCRIPT-1; EXPRESSION; ADENOCARCINOMA; PROGRESSION;

D O I：

10.3389/bjbs.2023.11103

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Colorectal cancer (CRC) is ranked as the third most common cancer and second deadliest cancer in both men and women in the world. Currently, the cure rate and 5-year survival rate of CRC patients remain relatively low. Therefore, discovering a novel molecular biomarker that can be used to improve CRC screening, diagnosis, prognosis, and treatment would be beneficial. Long non-coding RNA colon cancer-associated transcript 1 (CCAT 1) has been found overexpressed in CRC and is associated with CRC tumorigenesis and treatment outcome. CCAT 1 has a high degree of specificity and sensitivity, it is readily detected in CRC tissues and is significantly overexpressed in both premalignant and malignant CRC tissues. Besides, CCAT 1 is associated with clinical manifestation and advanced features of CRC, such as lymph node metastasis, high tumor node metastasis stage, differentiation, invasion, and distant metastasis. In addition, they can upregulate oncogenic c-MYC and negatively modulate microRNAs via different mechanisms of action. Furthermore, dysregulated CCAT 1 also enhances the chemoresistance in CRC cells while downregulation of them reverses the malignant phenotypes of cancer cells. In brief, CCAT 1 serves as a potential screening, diagnostic and prognostic biomarker in CRC, it also serves as a potential therapeutic marker to treat CRC patients.

引用

页数：10

共 91 条

[1] Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence [J].

Alaiyan, Bilal ;

Ilyayev, Nadia ;

Stojadinovic, Alexander ;

Izadjoo, Mina ;

Roistacher, Marina ;

Pavlov, Vera ;

Tzivin, Victoria ;

Halle, David ;

Pan, Honguang ;

Trink, Barry ;

Gure, Ali O. ;

Nissan, Aviram .

BMC CANCER, 2013, 13

[2] Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy [J].

Alqahtani, Ali ;

Choucair, Khalil ;

Ashraf, Mushtaq ;

Hammouda, Danae M. ;

Alloghbi, Abduraham ;

Khan, Talal ;

Senzer, Neil ;

Nemunaitis, John .

FUTURE SCIENCE OA, 2019, 5 (03)

[3] Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci [J].

Aznaourova, Marina ;

Schmerer, Nils ;

Schmeck, Bernd ;

Schulte, Leon N. .

FRONTIERS IN GENETICS, 2020, 11

[4] LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions [J].

Barbagallo, Cristina ;

Brex, Duilia ;

Caponnetto, Angela ;

Cimigliaro, Matilde ;

Scalia, Marina ;

Magnano, Antonio ;

Caltabiano, Rosario ;

Barbagallo, Davide ;

Biondi, Antonio ;

Cappellani, Alessandro ;

Basile, Francesco ;

Di Pietro, Cinzia ;

Purrello, Michele ;

Ragusa, Marco .

MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 12 :229-241

[5] Emerging roles of long non-coding RNA in cancer [J].

Calle, Anna Sanchez ;

Kawamura, Yumi ;

Yamamoto, Yusuke ;

Takeshita, Fumitaka ;

Ochiya, Takahiro .

CANCER SCIENCE, 2018, 109 (07) :2093-2100

[6] Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer [J].

Cao, Yuan ;

Shi, Huirong ;

Ren, Fang ;

Jia, Yanyan ;

Zhang, Ruitao .

EXPERIMENTAL CELL RESEARCH, 2017, 359 (01) :185-194

[7] Novel somatic mutations in heterotrimeric G proteins in melanoma [J].

Cardenas-Navia, L. Isabel ;

Cruz, Pedro ;

Lin, Jimmy C. ;

Rosenberg, Steven A. ;

Samuels, Yardena .

CANCER BIOLOGY & THERAPY, 2010, 10 (01) :33-37

[8] Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis [J].

Carlevaro-Fita, Joana ;

Lanzos, Andres ;

Feuerbach, Lars ;

Hong, Chen ;

Mas-Ponte, David ;

Pedersen, Jakob Skou ;

Johnson, Rory ;

Abascal, Federico ;

Amin, Samirkumar B. ;

Bader, Gary D. ;

Barenboim, Jonathan ;

Beroukhim, Rameen ;

Bertl, Johanna ;

Boroevich, Keith A. ;

Brunak, Soren ;

Campbell, Peter J. ;

Carlevaro-Fita, Joana ;

Chakravarty, Dimple ;

Chan, Calvin Wing Yiu ;

Chen, Ken ;

Choi, Jung Kyoon ;

Deu-Pons, Jordi ;

Dhingra, Priyanka ;

Diamanti, Klev ;

Feuerbach, Lars ;

Fink, J. Lynn ;

Fonseca, Nuno A. ;

Frigola, Joan ;

Gambacorti-Passerini, Carlo ;

Garsed, Dale W. ;

Gerstein, Mark ;

Getz, Gad ;

Gonzalez-Perez, Abel ;

Guo, Qianyun ;

Gut, Ivo G. ;

Haan, David ;

Hamilton, Mark P. ;

Haradhvala, Nicholas J. ;

Harmanci, Arif O. ;

Helmy, Mohamed ;

Herrmann, Carl ;

Hess, Julian M. ;

Hobolth, Asger ;

Hodzic, Ermin ;

Hong, Chen ;

Hornshoj, Henrik ;

Isaev, Keren ;

Izarzugaza, Jose M. G. ;

Johnson, Todd A. ;

Juul, Malene .

COMMUNICATIONS BIOLOGY, 2020, 3 (01)

[9] VEGF as a key mediator of angiogenesis in cancer [J].

Carmeliet, P .

ONCOLOGY, 2005, 69 :4-10

[10] Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia [J].

Chen, Lianxiang ;

Wang, Wei ;

Cao, Lixia ;

Li, Zhijun ;

Wang, Xing .

MOLECULES AND CELLS, 2016, 39 (04) :330-336

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