A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies

被引：3

作者：

Beatrici, Edoardo ^{[1
,2
]}

Frego, Nicola ^{[1
,2
]}

Chiarelli, Giuseppe ^{[1
,2
]}

Sordelli, Federica ^{[1
,2
]}

Mancon, Stefano ^{[1
,2
]}

Saitta, Cesare ^{[1
,2
]}

De Carne, Fabio ^{[1
,2
]}

Garofano, Giuseppe ^{[1
,2
]}

Arena, Paola ^{[1
,2
]}

Avolio, Pier Paolo ^{[1
,2
]}

Gobbo, Andrea ^{[1
,2
]}

Uleri, Alessandro ^{[1
,2
]}

Contieri, Roberto ^{[1
,2
]}

Paciotti, Marco ^{[2
]}

Lazzeri, Massimo ^{[2
]}

Hurle, Rodolfo ^{[2
]}

Casale, Paolo ^{[2
]}

Buffi, Nicolo Maria ^{[1
,2
]}

Lughezzani, Giovanni ^{[1
,2
]}

机构：

[1] Humanitas Univ, Dept Biomed Sci, I-20072 Pieve Emanuele, MI, Italy

[2] IRCCS Humanitas Res Hosp, Dept Urol, I-20089 Rozzano, MI, Italy

来源：

DIAGNOSTICS | 2024年 / 14卷 / 05期

关键词：

diagnosis; imaging; micro-ultrasound; multiparametric MRI; prostate cancer; prostate biopsy; MRI; OVERDIAGNOSIS; DIAGNOSIS; ACCURACY;

D O I：

10.3390/diagnostics14050525

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases. Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa). Results: In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15-37.8; p = 0.035). Conclusions: mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted.

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页数：14

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