Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke

被引：12

作者：

Jiang, Chengting ^{[1
,2
]}

Zhou, Yang ^{[3
]}

Chen, Rong ^{[2
]}

Yang, Mengjia ^{[1
,2
]}

Zhou, Haimei ^{[2
]}

Tang, Zhengxiu ^{[2
]}

Shi, Hongling ^{[4
]}

Qin, Dongdong ^{[1
,2
]}

机构：

[1] Yunnan Univ Chinese Med, Key Lab Tradit Chinese Med Prevent & Treatment Neu, Kunming 650500, Peoples R China

[2] Yunnan Univ Chinese Med, Sch Basic Med Sci, Kunming 650500, Peoples R China

[3] Yunnan Univ Chinese Med, Sch Clin Med 1, Kunming 650500, Peoples R China

[4] Yunnan Univ, Affiliated Hosp, Dept Rehabil Med, Kunming 650021, Peoples R China

来源：

PHARMACEUTICS | 2023年 / 15卷 / 12期

基金：

中国国家自然科学基金;

关键词：

ischemic stroke; nanomaterials; nanoparticles; drug delivery; targeted therapy; CEREBRAL-ISCHEMIA; EXTRACELLULAR VESICLES; TARGETED DELIVERY; BRAIN; NANOPARTICLES; NEUROPROTECTION; MECHANISMS; PENUMBRA; HEALTH; INJURY;

D O I：

10.3390/pharmaceutics15122669

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ischemic stroke is a leading cause of death and disability in the world. At present, reperfusion therapy and neuroprotective therapy, as guidelines for identifying effective and adjuvant treatment methods, are limited by treatment time windows, drug bioavailability, and side effects. Nanomaterial-based drug delivery systems have the characteristics of extending half-life, increasing bioavailability, targeting drug delivery, controllable drug release, and low toxicity, thus being used in the treatment of ischemic stroke to increase the therapeutic effects of drugs. Therefore, this review provides a comprehensive overview of nanomaterial-based drug delivery systems from nanocarriers, targeting ligands and stimulus factors of drug release, aiming to find the best combination of nanomaterial-based drug delivery systems for ischemic stroke. Finally, future research areas on nanomaterial-based drug delivery systems in ischemic stroke and the implications of the current knowledge for the development of novel treatment for ischemic stroke were identified.

引用

页数：25

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