Blood pressure and renal function responses in workers exposed to lead for up to six years

被引:1
作者
Yu, Yu-Ling [1 ,2 ]
An, De-Wei [1 ,2 ,3 ]
Yang, Wen-Yi [4 ]
Verhamme, Peter [5 ]
Allegaert, Karel [6 ,7 ,8 ]
Nawrot, Tim S. [1 ,9 ]
Staessen, Jan A. [2 ,10 ,11 ]
机构
[1] Univ Leuven, KU Leuven, Dept Publ Hlth & Primary Care, Res Unit Environm & Hlth, Leuven, Belgium
[2] Nonprofit Res Assoc Alliance Promot Prevent Med, Mechelen, Belgium
[3] Shanghai Jiao Tong Univ, Dept Cardiovasc Med, State Key Lab Med Genom, Sch Med,Ruijin Hosp,Natl Res Ctr Translat Med,Shan, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China
[5] Univ Leuven, KU Leuven, Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, Leuven, Belgium
[6] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium
[7] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium
[8] Erasmus MC, Dept Hosp Pharm, Rotterdam, Netherlands
[9] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium
[10] Univ Leuven, Fac Med, Biomed Sci Grp, Leuven, Belgium
[11] Nonprofit Res Assoc Alliance Promot Prevent Med, Leopoldstr 59, BE-2800 Mechelen, Belgium
关键词
blood pressure; hypertension; lead; occupational exposure; renal function; GLOMERULAR-FILTRATION-RATE; NATIONAL-HEALTH; UNITED-STATES; CYSTATIN C; BONE; ASSOCIATION; IMPAIRMENT; CREATININE; DECLINE; OFFICE;
D O I
10.1111/jch.14748
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure (BP) and renal function (RF) responses for up to 6 years in the workers without previous occupational lead exposure. BP was the average of five consecutive readings and the estimated glomerular filtration rate was derived from serum creatinine (eGFRcrt) and cystatin C (eGFRcys). Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 mu g/dL). The statistical methods included multivariable-adjusted mixed models and interval-censored Cox regression analysis. The 234 workers analyzed were on average 28.5 years old and included 91.9% men. The baseline BL concentration was 4.35 mu g/dL and increased 3.17-fold over follow-up (median: 2.03 years; range: 0.92-6.45 years). The changes in BP and RF were not significantly correlated with the follow-up-to-baseline BL ratio (p >= .51 and p >= .18, respectively). The fully-adjusted changes in systolic/diastolic BP associated with a doubling of BL were -0.25/-0.12 mm Hg (CI: -0.94 to 0.44/-0.66 to 0.42 mm Hg). Accordingly, the incidence of stage-1 or -2 hypertension was not associated with the BL change (p >= .063). Similarly, the changes in eGFRcrt and eGFRcys associated with a 3-fold BL increment were not significant, amounting to -0.70 mL/min/1.73 m2 (CI: -1.70 to 0.30 mL/min/1.73 m2) and -1.06 mL/min/1.73 m2 (-2.16 to 0.03 mL/min/1.73 m2). In conclusion, the BP and RF responses to an over 3-fold BL increment were small and not significant confirming the safety of modern lead-handing facilities operating under current safety rules.
引用
收藏
页码:1086 / 1095
页数:10
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