Liquid-Metal Core-Shell Particles Coated with Folate and Phospholipids for Targeted Drug Delivery and Photothermal Treatment of Cancer Cells

被引：7

作者：

Ahn, Suyeon ^{[1
]}

Kang, Seung Hyun ^{[2
]}

Woo, Hyunjeong ^{[1
]}

Kim, Kyobum ^{[3
]}

Koo, Hyung-Jun ^{[4
]}

Lee, Hee-Young ^{[5
]}

Choi, Yonghyun ^{[1
,6
]}

Kang, Shin Hyuk ^{[2
]}

Choi, Jonghoon ^{[1
,6
]}

机构：

[1] Chung Ang Univ, Sch Integrat Engn, Seoul 06974, South Korea

[2] Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Plast & Reconstruct Surg, Seoul 06973, South Korea

[3] Dongguk Univ, Dept Chem & Biochem Engn, Seoul 04620, South Korea

[4] Seoul Natl Univ Sci & Technol, Dept Chem & Biomol Engn, Seoul 01811, South Korea

[5] Kumoh Natl Inst Technol, Dept Chem Engn, Gumi 39177, South Korea

[6] Nanomedicine Corp, Feynman Inst Technol, Seoul 06974, South Korea

来源：

NANOMATERIALS | 2023年 / 13卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

liquid metal; eutectic gallium indium; cancer targeting; folate; photothermal; drug delivery system; THERAPY; CHEMOTHERAPY; APOPTOSIS; TOXICITY; RECEPTOR;

D O I：

10.3390/nano13132017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recently, several methods have been used for cancer treatment. Among them, chemotherapy is generally used, but general anticancer drugs may affect normal cells and tissues, causing various side effects. To reduce the side effects and increase the efficacy of anticancer drugs, a folate-based liquid-metal drug nanodelivery system was used to target the folate receptor, which is highly expressed in cancer cells. A phospholipid-based surface coating was formed on the surface of liquid-metal nanoparticles to increase their stability, and doxorubicin was loaded as a drug delivery system. Folate on the lipid shell surface increased the efficiency of targeting cancer cells. The photothermal properties of liquid metal were confirmed by near-infrared (NIR) laser irradiation. After treating cancerous and normal cells with liquid-metal particles and NIR irradiation, the particles were specifically bound to cancer cells for drug uptake, confirming photothermal therapy as a drug delivery system that is expected to induce cancer cell death through comprehensive effects such as vascular embolization in addition to targeting cancer cells.

引用

页数：14

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