African Swine Fever Virus Interaction with Host Innate Immune Factors

被引：12
|
作者：
Afe, Ayoola Ebenezer [1 ,2 ]
Shen, Zhao-Ji [2 ]
Guo, Xiaorong [3 ]
Zhou, Rong [2 ]
Li, Kui [1 ]
机构：
[1] Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr,Key Lab Livestock, Shenzhen 518000, Peoples R China
[2] Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Biotech Breeding, Beijing 100193, Peoples R China
[3] Foshan Univ, Guangdong Prov Key Lab Anim Mol Design & Precise B, Foshan 528231, Peoples R China
来源：
VIRUSES-BASEL | 2023年 / 15卷 / 06期
基金：
中国国家自然科学基金;
关键词：
ASF; ASFV; virus virulence; pathogenesis in natural host; protective host immune response; NF-KAPPA-B; EDITED PIGS; INFECTION; ACTIVATION; INDUCTION; PHOSPHATASE; EIF2-ALPHA; RESPONSES; PATHWAY; ISOLATE;
D O I：
10.3390/v15061220
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
African swine fever virus (ASFV) adversely affects pig farming owing to its 100% mortality rate. The condition is marked by elevated body temperature, bleeding, and ataxia in domestic pigs, whereas warthogs and ticks remain asymptomatic despite being natural reservoirs for the virus. Breeding ASFV-resistant pigs is a promising solution for eradicating this disease. ASFV employs several mechanisms to deplete the host antiviral response. This review explores the interaction of ASFV proteins with innate host immunity and the various types of machinery encompassed by viral proteins that inhibit and induce different signaling pathways, such as cGAS-STING, NF-& kappa;B, Tumor growth factor-beta (TGF-& beta;), ubiquitination, viral inhibition of apoptosis, and resistance to ASFV infection. Prospects for developing a domestic pig that is resistant to ASFV are also discussed.
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页数：17
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