Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture

被引：4

作者：

Radmand, Samira ^{[1
,2
,3
]}

Rezaei, Homa ^{[1
,2
,3
]}

Zhao, Hongkun ^{[4
]}

Rahimpour, Elaheh ^{[2
,3
,5
]}

Jouyban, Abolghasem ^{[2
,3
,6
]}

机构：

[1] Tabriz Univ Med Sci, Student Res Comm, Fac Pharm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] YangZhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[5] Tabriz Univ Med Sci, Infect & Trop Dis Res Ctr, Tabriz, Iran

[6] Near East Univ, Fac Pharm, POB 99138,Mersin 10, Nicosia, North Cyprus, Turkiye

来源：

BMC CHEMISTRY | 2023年 / 17卷 / 01期

关键词：

Deferiprone; Solubility; Binary solvent mixture; Cosolvency models; Thermodynamic properties; PREDICTION; WATER; SOLVENTS; MODEL;

D O I：

10.1186/s13065-023-00950-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid-liquid equilibration and the spectrophotometry method was employed for solubility measurement. Solubility and density of deferiprone in non-aqueous mixtures of propylene glycol and ethanol were measured in the temperatures 293.2-313.2 K. Some equations including van't Hoff, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, the mixture response surface and modified Wilson equations were used for the mathematical data modeling. The apparent thermodynamic parameters of the deferiprone dissolution process were computed and reported.

引用

页数：10

共 27 条

[1] Prediction of deferiprone solubility in aqueous mixtures of ethylene glycol, propylene glycol and polyethylene glycol 400 at various temperatures [J].