Significant anti-inflammatory aziridine-containing indole alkaloids from the Chinese medicinal plant Alstonia scholaris

被引：11

作者：

Hu, Bin-Yuan ^{[1
]}

Zhao, Yun-Li ^{[1
]}

Zhou, Zhong-Shun ^{[1
]}

Zhu, Yan-Yan ^{[1
]}

Luo, Xiao-Dong ^{[1
,2
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Yunnan Characterist Plant Extract Lab, Key Lab Med Chem Nat Resource,Minist Educ & Yunnan, Kunming 650501, Peoples R China

[2] Chinese Acad Sci Kunming, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Kunming 650201, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 16期

关键词：

LEAVES; PORFIROMYCIN;

D O I：

10.1039/d2cc07029d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two unique windmill-like aziridine-containing indole alkaloids, possessing an unprecedented 6/5/5/6/6/5/3 rigid ring system and an unusual azabicyclo[3.1.0]hexane core, were isolated from Alstonia scholaris. Their structures were established by spectroscopy, X-ray diffraction, and electronic circular dichroism calculations. The novel compounds exhibited significant anti-inflammatory bioactivity in vitro and alleviated LPS-induced acute lung injury in mice.

引用

页码：2271 / 2274

页数：4

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