Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

被引：18

作者：

Elhakeem, Ahmed ^{[1
,2
]}

Taylor, Amy E. ^{[1
,2
,3
]}

Inskip, Hazel M. ^{[4
]}

Huang, Jonathan Y. ^{[5
,6
]}

Mansell, Toby ^{[7
,8
]}

Rodrigues, Carina ^{[9
,10
]}

Asta, Federica ^{[11
]}

Blaauwendraad, Sophia M. ^{[12
,13
]}

Haberg, Siri E. ^{[14
]}

Halliday, Jane ^{[7
,8
]}

Harskamp-van Ginkel, Margreet W. ^{[15
]}

He, Jian-Rong ^{[16
]}

Jaddoe, Vincent W. V. ^{[12
,13
]}

Lewis, Sharon ^{[7
,8
]}

Maher, Gillian M. ^{[17
,18
]}

Manios, Yannis ^{[19
,20
]}

McCarthy, Fergus P. ^{[18
,21
]}

Reiss, Irwin K. M. ^{[13
]}

Rusconi, Franca ^{[22
,23
]}

Salika, Theodosia ^{[4
]}

Tafflet, Muriel ^{[24
]}

Qiu, Xiu ^{[16
]}

Asvold, Bjorn O. ^{[25
,26
,27
,28
]}

Burgner, David ^{[7
,29
,30
]}

Chan, Jerry K. Y. ^{[31
,32
]}

Gagliardi, Luigi ^{[22
,23
]}

Gaillard, Romy ^{[12
,13
]}

Heude, Barbara ^{[24
]}

Magnus, Maria C. ^{[14
]}

Moschonis, George ^{[33
]}

Murray, Deirdre ^{[18
,34
,35
]}

Nelson, Scott M. ^{[3
,36
,37
]}

Porta, Daniela ^{[11
]}

Saffery, Richard ^{[7
,8
]}

Barros, Henrique ^{[9
,10
]}

Eriksson, Johan G. ^{[5
,38
]}

Vrijkotte, Tanja G. M. ^{[15
]}

Lawlor, Deborah A. ^{[1
,2
,3
]}

机构：

[1] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, England

[2] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England

[3] NIHR Bristol Biomed Res Ctr, Bristol, England

[4] Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England

[5] Singapore Inst Clin Sci, Agcy Sci Res & Technol, Singapore, Singapore

[6] Duke NUS Med Sch, Ctr Quantitat Med, Singapore, Singapore

[7] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic, Australia

[8] Univ Melbourne, Parkville, Vic, Australia

[9] Univ Porto, Inst Saude Publ, EPIUnit, Porto, Portugal

[10] Lab Invest Integrat & Translac Saude Populac ITR, Porto, Portugal

[11] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

[12] Univ Med Ctr, Generat Study Grp R, Erasmus MC, Rotterdam, Netherlands

[13] Univ Med Ctr, Dept Paediat, Erasmus MC, Rotterdam, Netherlands

[14] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway

[15] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands

[16] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Div Birth Cohort Study, Guangzhou, Peoples R China

[17] Univ Coll Cork, Sch Publ Hlth, Cork, Ireland

[18] Univ Coll Cork, Irish Ctr Maternal & Child Hlth Res INFANT, Cork, Ireland

[19] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece

[20] Hellen Mediterranean Univ Res Ctr, Inst Agrifood & Life Sci, Iraklion, Greece

[21] Univ Coll Cork, Dept Obstet & Gynaecol, Cork, Ireland

[22] AUSL Toscana Nord Ovest, Osped Versilia, Dept Mother & Child Hlth, Pisa, Italy

[23] Univ Paris Cite, Paris, France

[24] Univ Sorbonne Paris Nord, Ctr Res Epidemiol & Stat CRESS, INSERM, INRAE, Paris, France

[25] Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Fac Med & Hlth Sci, Trondheim, Norway

[26] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Endocrinol, Clin Med, Trondheim, Norway

[27] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia

[28] Monash Univ, Dept Paediat, Clayton, Vic, Australia

[29] KK Womens & Childrens Hosp, Dept Reprod Med, Singapore, Singapore

[30] Duke NUS Med Sch, Acad Clin Program Obstet & Gynaecol, Singapore, Singapore

[31] La Trobe Univ, Dept Food Nutr & Dietet, Sch Allied Hlth Human Serv & Sport, Coll Sci Hlth & Engn, Melbourne, Australia

[32] Univ Coll Cork, Dept Pediat & Child Hlth, Cork, Ireland

[33] Univ Glasgow, Sch Med, Glasgow, Scotland

[34] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore

[35] Natl Univ Singapore, Human Potential Translat Res Programme, Yong Loo Lin Sch Med, Singapore, Singapore

[36] Univ Helsinki, Helsinki Univ Hosp, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland

[37] Helsinki Univ Hosp, Helsinki, Finland

[38] Folkhalsan Res Ctr, Helsinki, Finland

来源：

EUROPEAN HEART JOURNAL | 2023年 / 44卷 / 16期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Blood pressure; Glucose; In vitro fertilization; Lipids; Meta-analysis; Pooled longitudinal trajectory analysis; CARDIOVASCULAR-DISEASE; ASSOCIATION; CHILDREN; DEFECTS; BIRTH; RISK;

D O I：

10.1093/eurheartj/ehac726

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (-0.53 mmHg; 95% CI:-1.59 to 0.53), DBP (-0.24 mmHg; -0.83 to 0.35), or HR (0.02 beat/min; -0.91 to 0.94). Total cholesterol (2.59%; 0.10-5.07), HDL cholesterol (4.16%; 2.52-5.81), LDL cholesterol (4.95%; 0.47-9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant. Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.

引用

页码：1464 / +

页数：11

共 59 条

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