Bone Mineral Density and Serum 25OHD in Children and Adolescents With Juvenile Idiopathic Arthritis

被引：6
作者：
Charuvanij, Sirirat [1 ]
Malakorn, Hathaikan [1 ]
Densupsoontorn, Narumon [2 ]
Nakavachara, Pairunyar [3 ]
机构：
[1] Mahidol Univ, Siriraj Hosp, Fac Med, Div Rheumatol,Dept Pediat, Bangkok, Thailand
[2] Mahidol Univ, Fac Med, Dept Pediat, Div Nutr,Siriraj Hosp, Bangkok, Thailand
[3] Mahidol Univ, Fac Med, Dept Pediat, Div Pediat Endocrinol,Siriraj Hosp, Bangkok 10700, Thailand
来源：
CLINICAL PEDIATRICS | 2023年 / 62卷 / 05期
关键词：
bone mineral density; children; juvenile idiopathic arthritis; vitamin D; 25OHD; X-RAY ABSORPTIOMETRY; YOUNG-ADULTS; VERTEBRAL FRACTURES; PUBERTAL CHANGES; MASS; HEALTH; DETERMINANTS; VALIDATION; DEFICIENCY; CHILDHOOD;
D O I：
10.1177/00099228221136982
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Low bone mass is one of the complications of juvenile idiopathic arthritis (JIA). However, a study focusing on the low bone mass in children and adolescents with JIA in Southeast Asian countries is limited. This study aimed to evaluate the bone mineral density (BMD) of Thai patients with JIA and identify factors correlated with BMD. A cross-sectional study was conducted at a tertiary-care center. The BMD of the lumbar spines (BMDLS) and the total body (BMDTB) were measured by dual-energy X-ray absorptiometry. Thirty-eight patients were enrolled between July 2015 and January 2016. No patient had low BMDLS, and only 2 (5.3%) had low BMDTB. Serum 25-hydroxyvitamin D (25OHD) levels were significantly positively correlated with the BMDTB Z-score (coefficient: 0.047; 95% confidence interval = 0.011-0.082; P = .012). Our study demonstrated a very low prevalence of low bone mass. Optimization of the serum 25OHD level should be encouraged.
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收藏
页码：456 / 465
页数：10
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