Modulating Lipid Membrane Morphology by Dynamic DNA Origami Networks

被引：7

作者：

Yang, Juanjuan ^{[1
,2
]}

Jahnke, Kevin ^{[3
,4
]}

Xin, Ling ^{[2
]}

Jing, Xinxin ^{[2
]}

Zhan, Pengfei ^{[2
]}

Peil, Andreas ^{[2
]}

Griffo, Alessandra ^{[3
]}

Skugor, Marko ^{[2
]}

Yang, Donglei ^{[1
]}

Fan, Sisi ^{[2
]}

Goepfrich, Kerstin ^{[3
,5
]}

Yan, Hao ^{[6
,7
]}

Wang, Pengfei ^{[1
]}

Liu, Na ^{[2
,8
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Shanghai Key Lab Nucl Acid Chem & Nanomed,Dept Lab, Shanghai 200127, Peoples R China

[2] Univ Stuttgart, Phys Inst 2, D-70569 Stuttgart, Germany

[3] Max Planck Inst Med Res Heidelberg, Biophys Engn Grp, D-69120 Heidelberg, Germany

[4] Harvard Univ, Sch Engn & Appl Sci, 9 Oxford St, Cambridge, MA USA

[5] Ctr Mol Biol Heidelberg Univ ZMBH, D-69120 Heidelberg, Germany

[6] Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA

[7] Arizona State Univ, Biodesign Inst, Ctr Mol Design & Biomimet, Tempe, AZ 85287 USA

[8] Max Planck Inst Solid State Res, D-70569 Stuttgart, Germany

来源：

NANO LETTERS | 2023年 / 23卷 / 14期

基金：

欧盟地平线“2020”; 中国国家自然科学基金;

关键词：

DNA origami; self-assembly; DNA networks; dynamic DNA nanotechnology; membrane curvature; giant unilamellar lipid vesicles (GUVs); FOLDING DNA; CURVATURE; SHAPES;

D O I：

10.1021/acs.nanolett.3c00750

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Membrane morphology and its dynamic adaptation regulatemany cellularfunctions, which are often mediated by membrane proteins. Advancesin DNA nanotechnology have enabled the realization of various protein-inspiredstructures and functions with precise control at the nanometer level,suggesting a viable tool to artificially engineer membrane morphology.In this work, we demonstrate a DNA origami cross (DOC) structure thatcan be anchored onto giant unilamellar vesicles (GUVs) and subsequentlypolymerized into micrometer-scale reconfigurable one-dimensional (1D)chains or two-dimensional (2D) lattices. Such DNA origami-based networkscan be switched between left-handed (LH) and right-handed (RH) conformationsby DNA fuels and exhibit potent efficacy in remodeling the membranecurvatures of GUVs. This work sheds light on designing hierarchicallyassembled dynamic DNA systems for the programmable modulation of syntheticcells for useful applications.

引用

页码：6330 / 6336

页数：7

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