Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity

被引：29
|
作者：
Salathia, Saniya [1 ]
Gigliobianco, Maria Rosa [1 ]
Casadidio, Cristina [1 ]
Di Martino, Piera [1 ,2 ]
Censi, Roberta [1 ]
机构：
[1] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy
[2] Univ G Annunzio Chieti & Pescara, Dept Pharm, I-66100 Chieti, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 08期
关键词：
hyaluronic acid; CD44; nanosystems; antinociceptive; anti-inflammatory; NANOSTRUCTURED LIPID CARRIERS; C-REACTIVE PROTEIN; NEURO-IMMUNE INTERACTIONS; INDUCED INFLAMMATION; DRUG-DELIVERY; IN-VITRO; TRANSDERMAL DELIVERY; POTENTIAL CARRIER; TOPICAL DELIVERY; NANOPARTICLES;
D O I：
10.3390/ijms24087286
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nervous and immune systems go hand in hand in causing inflammation and pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others are caused by it. Macrophages play an important role in modulating inflammation to trigger neuropathic pain. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a well-known ability to bind with the cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving inflammation by varying the molecular weight of HA is a debated concept. HA-based drug delivery nanosystems such as nanohydrogels and nanoemulsions, targeting macrophages can be used to relieve pain and inflammation by loading antinociceptive drugs and enhancing the effect of anti-inflammatory drugs. This review will discuss the ongoing research on HA-based drug delivery nanosystems regarding their antinociceptive and anti-inflammatory effects.
引用
收藏
页数：21
相关论文
共 50 条
  • [1] Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors
    Ganesh, Shanthi
    Iyer, Arun K.
    Morrissey, David V.
    Amiji, Mansoor M.
    BIOMATERIALS, 2013, 34 (13) : 3489 - 3502
  • [2] Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction
    Rezaeeyazdi, Mahboobeh
    Colombani, Thibault
    Eggermont, Loek J.
    Bencherif, Sidi A.
    MATERIALS TODAY BIO, 2022, 13
  • [3] CD44-Targeted Carriers: The Role of Molecular Weight of Hyaluronic Acid in the Uptake of Hyaluronic Acid-Based Nanoparticles
    Chiesa, Enrica
    Greco, Antonietta
    Riva, Federica
    Dorati, Rossella
    Conti, Bice
    Modena, Tiziana
    Genta, Ida
    PHARMACEUTICALS, 2022, 15 (01)
  • [4] Hyaluronic acid-based label-free electrochemical impedance analysis for cancer cell quantification and CD44 expression
    Zhou, Yaping
    Wan, Yao
    Yu, Ming
    Yuan, Xiaoyan
    Zhang, Chengjiang
    MICROCHEMICAL JOURNAL, 2021, 160
  • [5] Anti-inflammatory and Antioxidant Potential of Hyaluronic Acid Mediated Zinc Nanoparticles
    Akash, N.
    Arivarasu, Lakshminarayanan
    Rajeshkumar, S.
    JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2020, 32 (20) : 33 - 37
  • [6] Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa
    Brito da Matta, Carolina Babosa
    de Souza, Everton Tenorio
    de Queiroz, Aline Cavalcanti
    de Lira, Daysianne Pereira
    de Araujo, Morgana Vital
    Agra Cavalcante-Silva, Luiz Henrique
    de Miranda, George Emmanuel C.
    de Araujo-Junior, Joao Xavier
    Barbosa-Filho, Jose Maria
    de Oliveira Santos, Barbara Viviana
    Alexandre-Moreira, Magna Suzana
    MARINE DRUGS, 2011, 9 (03) : 307 - 318
  • [7] Smart Nanoparticles Based on Hyaluronic Acid for Redox-Responsive and CD44 Receptor-Mediated Targeting of Tumor
    Park, Hyung-Kyu
    Lee, Sang Joon
    Oh, Jong-Suk
    Lee, Sam-Gyu
    Jeong, Young-Il
    Lee, Hyun Chul
    NANOSCALE RESEARCH LETTERS, 2015, 10
  • [8] Smart Nanoparticles Based on Hyaluronic Acid for Redox-Responsive and CD44 Receptor-Mediated Targeting of Tumor
    Hyung-Kyu Park
    Sang Joon Lee
    Jong-Suk Oh
    Sam-Gyu Lee
    Young-IL Jeong
    Hyun Chul Lee
    Nanoscale Research Letters, 2015, 10
  • [9] Sulfation Modulates the Targeting Properties of Hyaluronic Acid to P-Selectin and CD44
    Bhattacharya, Deep S.
    Svechkarev, Denis
    Bapat, Aishwarya
    Patil, Prathamesh
    Hollingsworth, Michael A.
    Mohs, Aaron M.
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 6 (06) : 3585 - 3598
  • [10] Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
    Mattheolabakis, George
    Milane, Lara
    Singh, Amit
    Amiji, Mansoor M.
    JOURNAL OF DRUG TARGETING, 2015, 23 (7-8) : 605 - 618
12345