Lung fibrosis: Post-COVID-19 complications and evidences

被引：23

作者：

Hirawat, Rishabh ^{[1
]}

Jain, Namrata ^{[1
]}

Saifi, Mohd Aslam ^{[1
]}

Rachamalla, Mahesh ^{[2
]}

Godugu, Chandraiah ^{[1
,3
]}

机构：

[1] NIPER Hyderabad, Dept Biol Sci, Hyderabad, India

[2] Univ Saskatchewan, Dept Biol, Saskatoon, SK S7N 5E2, Canada

[3] Natl Inst Pharmaceut Educ & Res NIPER, Dept Biol Sci Regulatory Toxicol, Hyderabad 500037, India

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 116卷

关键词：

COVID-19; Pulmonary fibrosis; Epithelial-mesenchymal transition; TGF-beta; WNT; YAP/TAZ; ANGIOTENSIN-CONVERTING ENZYME-2; RESPIRATORY-DISTRESS-SYNDROME; TGF-BETA; PULMONARY-FIBROSIS; MESENCHYMAL TRANSITION; HIPPO PATHWAY; COVID-19; SARS; CELLS; MECHANISMS;

D O I：

10.1016/j.intimp.2022.109418

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: COVID 19, a lethal viral outbreak that devastated lives and the economy across the globe witnessed non-compensable respiratory illnesses in patients. As been evaluated in reports, patients receiving long-term treatment are more prone to acquire Pulmonary Fibrosis (PF). Repetitive damage and repair of alveolar tissues increase oxidative stress, inflammation and elevated production of fibrotic proteins ultimately disrupting normal lung physiology skewing the balance towards the fibrotic milieu. Aim: In the present work, we have discussed several important pathways which are involved in post-COVID PF. Further, we have also highlighted the rationale for the use of antifibrotic agents for post-COVID PF to decrease the burden and improve pulmonary functions in COVID-19 patients. Conclusion: Based on the available literature and recent incidences, it is crucial to monitor COVID-19 patients over a period of time to rule out the possibility of residual effects. There is a need for concrete evidence to deeply understand the mechanisms responsible for PF in COVID-19 patients.

引用

页数：11

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