Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications

被引：158

作者：

Zheng, Shanliang ^{[1
]}

Wang, Xingwen ^{[1
]}

Zhao, Dong ^{[1
]}

Liu, Hao ^{[1
]}

Hu, Ying ^{[1
]}

机构：

[1] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Heilongjiang, Peoples R China

来源：

TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 04期

基金：

中国国家自然科学基金;

关键词：

INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; IP3R3-MEDIATED CA2+ FLUX; COLORECTAL-CANCER; REGULATES APOPTOSIS; RESISTANCE; INHIBITION; CELLS; IASPP; ENTRY; STIM1;

D O I：

10.1016/j.tcb.2022.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium ion (Ca2+) is a ubiquitous and versatile signaling molecule controlling a wide variety of cellular processes, such as proliferation, cell death, migration, and immune response, all fundamental processes essential for the establish-ment of cancer. In recent decades, the loss of Ca2+ homeostasis has been con-sidered an important driving force in the initiation and progression of malignant diseases. The primary intracellular Ca2+ store, the endoplasmic reticulum (ER), plays an essential role in maintaining Ca2+ homeostasis by coordinating with other organelles and the plasma membrane. Here, we discuss the dysregulation of ER-centered Ca2+ homeostasis in cancer, summarize Ca2+-based anticancer therapeutics, and highlight the significance of furthering our understanding of Ca2+ homeostasis regulation in cancer.

引用

页码：312 / 323

页数：12

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