Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies

被引：5

作者：

Armstrong, Melissa J. ^{[1
,2
]}

LaBarre, Brian ^{[3
]}

Sovich, Kaitlin ^{[1
]}

Maixner, Susan M. ^{[4
]}

Paulson, Henry L. ^{[5
]}

Manning, Carol ^{[6
]}

Fields, Julie A. ^{[7
]}

Lunde, Angela ^{[8
]}

Forsberg, Leah ^{[8
]}

Boeve, Bradley F. ^{[8
]}

Galvin, James E. ^{[9
]}

Taylor, Angela S. ^{[10
]}

Li, Zhigang ^{[3
]}

机构：

[1] Univ Florida, Dept Neurol, Coll Med, Gainesville, FL USA

[2] Norman Fixel Inst Neurol Dis, Gainesville, FL USA

[3] Univ Florida, Dept Biostat, Coll Med, Gainesville, FL USA

[4] Univ Michigan, Dept Psychiat, Ann Arbor, MI USA

[5] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

[6] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[7] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA

[8] Mayo Clin, Dept Neurol, Rochester, MN USA

[9] Univ Miami, Dept Neurol, Comprehens Ctr Brain Hlth, Miller Sch Med, Miami, FL USA

[10] Lewy Body Dementia Assoc, Lilburn, GA USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 04期

关键词：

caregivers; dementia; dementia with Lewy bodies; Lewy body disease; quality of life; MULTIDIMENSIONAL SCALE; RELIABILITY; CAREGIVERS; INVENTORY; INTERVIEW; VALIDITY; PEOPLE; BURDEN; FORM; AD;

D O I：

10.1002/alz.13745

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Little is known regarding quality of life (QoL) in dementia with Lewy bodies (DLB), particularly in advanced stages. METHODS: Dyads of individuals with moderate-advanced DLB and their primary caregivers were recruited from specialty clinics, advocacy organizations, and research registries. The study collected demographics, disease-relatedmeasures, andmeasures of patient/caregiver experiences. RESULTS: The Quality of Life in Alzheimer's Disease (QoL-AD) was completed by the person with DLB and the caregiver (proxy) in 61 dyads; 85 dyads had only a proxy-completed QoL-AD. Patient- and proxy-reported scores were moderately correlated (r= 0.57, P< 0.0001). Worse patient-reportedQoLcorrelatedwith daytime sleepiness, autonomic symptom burden, and behavioral symptoms. Proxy ratings correlated with dementia severity, daytime sleepiness, behavioral symptoms, dependence in activities of daily living, and caregiver experience measures. DISCUSSION: Patient- and proxy-reported quality of life (QoL) should be assessed separately in advanced DLB. Some symptoms associated with QoL have available therapeutic options. Research is needed regarding strategies to optimally improve QoL in DLB.

引用

页码：2719 / 2730

页数：12

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