Pleosmaranes A-R, Isopimarane and 20-nor Isopimarane Diterpenoids with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Pleosporales sp. HNQQJ-1

被引：6
作者：
Wang, Guisheng [1 ,2 ,3 ]
Yuan, Yilin [2 ]
Li, Zhaokun [1 ]
Liu, Xuguang [2 ]
Chu, Yanhai [2 ]
She, Zhigang [3 ]
Kang, Wenyi [2 ]
Chen, Yan [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
[2] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China
[3] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2024年 / 87卷 / 02期
基金：
中国国家自然科学基金;
关键词：
DERIVATIVES;
D O I：
10.1021/acs.jnatprod.3c00893
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Pleosmaranes A-R (1-18), 18 new isopimarane-type diterpenoids, together with four known analogs (19-22), were isolated from the mangrove endophytic fungus Pleosporales sp. HNQQJ-1. Their structures and absolute configurations were established by analysis of their spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-9 possess an unusual aromatic B ring and a 20-nor-isopimarane skeleton. Compounds 15-17 contain a unique 2-oxabicyclo[2.2.2]octane moiety. Compound 18 features an unexpected 2-oxabicyclo[3.2.1]octane moiety. Compounds 8 and 12 exhibited a moderate inhibitory effect against LPS-induced NO production, with IC50 values of 19 and 25 mu M, respectively.
引用
收藏
页码：304 / 314
页数：11
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