Comparative Study of Porous Iron Foams for Biodegradable Implants: Structural Analysis and In Vitro Assessment

被引：1

作者：

Gasior, Gabriela ^{[1
]}

Grodzicka, Marlena ^{[1
]}

Jedrzejewski, Tomasz ^{[2
]}

Wisniewski, Marek ^{[1
]}

Radtke, Aleksandra ^{[1
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina St 7, PL-87100 Torun, Poland

[2] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Lwowska St 1, PL-87100 Torun, Poland

来源：

JOURNAL OF FUNCTIONAL BIOMATERIALS | 2023年 / 14卷 / 06期

关键词：

iron; iron-based materials; porosity; biodegradable metals; corrosion; cytotoxic activity; PURE IRON; PULMONARY-ARTERY; DEGRADATION; STENTS; CELLS; CYTOTOXICITY; BIOMATERIAL; IMMERSION; METALS;

D O I：

10.3390/jfb14060293

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Biodegradable metal systems are the future of modern implantology. This publication describes the preparation of porous iron-based materials using a simple, affordable replica method on a polymeric template. We obtained two iron-based materials with different pore sizes for potential application in cardiac surgery implants. The materials were compared in terms of their corrosion rate (using immersion and electrochemical methods) and their cytotoxic activity (indirect test on three cell lines: mouse L929 fibroblasts, human aortic smooth muscle cells (HAMSC), and human umbilical vein endothelial cells (HUVEC)). Our research proved that the material being too porous might have a toxic effect on cell lines due to rapid corrosion.

引用

页数：18

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